Médiateurs chimiques Flashcards

1
Q

Source: mastocytes, basophiles, plaquettes
Action: vasodilatation, perméabilité vasculaire

A

Histamine

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2
Q

Source: Hépatocytes (plasma)
Action: Activation et chimiotaxie des leucocytes, MAC, vasodilatation par stimulation des mastocytes

A

Complément

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3
Q

Source: Hépatocytes (plasma)
Action: Perméabilité vasculaire, contraction musculaire lisse, vasodilatation, douleur

A

Kinines

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4
Q

Source: mastocytes, leucocytes
Action: Vasodilatation, douleur, fièvre

A

Prostaglandines

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5
Q

Source: mastocytes, leucocytes
Action: perméabilité vasculaire, chimiotaxie

A

Leucotriènes

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6
Q

Source: Leucocytes, mastocytes
Action: Chimiotaxie

A

Facteur d’activation plaquettaire (PAF)

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7
Q

Source: macrophages, cellules endothéliales, mastocytes
Action: locale (activation endothéliale), systémique (fièvre, hypotension/choc)

A

Cytokines (TNF, IL-1)

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8
Q

Source: macrophages, cellules endothéliales
Action: diminue la réaction inflammatoire, effect bactéricide

A

Oxyde nitrique (NO)

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9
Q

Source: macrophages, neutrophiles
Action: destruction (micro-organismes/tissu endommagé)

A

Enzymes lysosomiales (radicaux libres aussi)

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10
Q

Source: macrophages, neutrophiles
Action: destruction (micro-organismes/tissu endommagé)

A

Radicaux libres (enzymes lysosomiales aussi)

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11
Q

Source: nerfs sensitifs, leucocytes
Action: douleur, perméabilité vasculaire, tonus vasculaire

A

Neuropeptides

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12
Q

Vasodilatation

A

Histamine, PG

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13
Q

Perméabilité vasculaire

A

Histamine, complément, LT

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14
Q

Chimiotaxie

A

Chimiokines (TNF, IL-1), complément, LT

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15
Q

Fièvre

A

Chimiokines (TNF, IL-1), PG

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16
Q

Douleur

A

PG, bradykinine, neuropeptides

17
Q

Dommage tissulaire

A

enzymes lysosomiales, ROS