MedGems Histopath

Question 1

MOA of Bicalutamide - treatment for metastatic prostate cancer

Answer 1

Androgen Antagonist

Question 2

Other than zinc, what is the first line pharmacological treatment for Wilson’s disease?

Answer 2

Trientine

Question 3

What histopathological description is given to cells that have lost their intercellular connections between neighbouring cells?

An example could be the loss of desmosomal connections in pemphigus vulgaris.

Answer 3

Acantholysis

Question 4

What protein is defective in adult polycystic kidney disease?

Answer 4

Polycystin-1

Question 5

What sign describes painless jaundice in the presence of a palpable gallbladder?

Answer 5

Courvoisier’s sign

Question 6

What is the most common histochemical stain used to visualise cells for light microscopy, such as that used for diagnosis of cancers?

Answer 6

Haematoxylin and Eosin

Question 7

What spirometry pattern is characterised by a reduced FEV1, reduced FVC and a normal FEV1/FVC ratio?

Answer 7

Restrictive