MEDGEMS

Question 1

how to differentiate between haemophilia and vWD

Answer 1

haemophilia wont affect bleeding time

Question 2

reversal agent for rivaroxiban

Answer 2

adenexat alpha

Question 3

what condition is associated with a megakaryocyte infiltration into the bone marrow

Answer 3

essential thrombycytosis

Question 4

what inherited condition, after cystic fibrosis, is the most common cause of pancreatic exocrine dysfunction in children

Answer 4

shwachmann diamond syndrome

Question 5

G6PD inheritance

Answer 5

x linked recessive

Question 6

first line small molecule inhibitor is used in the treatment of chronic lymphocytic leukaemia

Answer 6

ibrutinib

Question 7

what description is given to red blood cells which are typically polychromatic and stain heavily for the presence of RNA

Answer 7

reticulocyte

Question 8

abnormality in
fanconi anaemia
dyskaryosis congenita
diamond blackfan syndrome
shwachmann diamond syndrome

Answer 8

fanconi anaemia= pancytopenia
dyskaryosis congenita= pancytopenia
diamond blackfan syndrome= RBC deficiency
shwachmann diamond syndrome= lack of neutrophils

Question 9

autoantibodies in heparin induced thrombocytopenia

Answer 9

heparin
platelet factor 4

Question 10

cd15 and cd5 marker in a patient with lymphadenopathy and raised white cell count

Answer 10

chronic lymphocytic leukaemia

Question 11

what clotting factor has the shortest half life

Answer 11

7

Question 12

what is first line anticoagulant in DVT

Answer 12

DOAC

Question 13

what cancer is associated with fanconi syndrome

Answer 13

acute myeloid leukaemia
10% chance of developing it

Question 14

what anticoagulant is given in DVT if someone has renal failure

Answer 14

warfarin

Question 15

haemophilia a and b inheritance

Answer 15

x linked recessive

Question 16

myeloproliferative syndromes carry the risk of transformation into what malignancy

Answer 16

acute myeloid leukaemia

Question 17

what are the 2 bilobed cells on blood film and how do you differentiate them

Answer 17

basophil= has blue granules
eosinophil= has red/brown granules

Question 18

how is LMWH heparin reversed

Answer 18

protamine sulfate

Question 19

diamond blackfan anaemia presentation

Answer 19

infancy
anaemia, low reticulocytes, high foetal haemoglobin
cleft palate, cardiac defects, craniofacial malformation

Question 20

what imaging modality is used for staging in hodgkins lymphoma

Answer 20

PET-CT

Question 21

how do you differentiate
haemophilia a trait
haemoglobin H disease
hydrops fetalis

Answer 21

haemophilia a trait= 1 or 2 defective genes
haemoglobin H disease= 3 defective genes
hydrops fetalis= 4 defective genes

Question 22

south mediterranean woman with low haemoglobin and MCV

Answer 22

thalassaemia

Question 23

how to slowly vs rapidly reverse warfarin

Answer 23

slowly= IV vitamin K
quickly= prothrombin complex concentrate

Question 24

what medication increases the production of HbF and can be used in sickle cell and thalassaemias

Answer 24

hydroxycarbamide

Question 25

what coagulation factor increases after starting warfarin and causes a pro thrombotic state

Answer 25

protein c and s

Question 26

hepatic cancer is associated with what medication

Answer 26

OCP

Question 27

child with flank mass and microscopic haematuria

Answer 27

nephroblastoma

Question 28

how many grams of glucose given in ogtt

Answer 28

75

Question 29

in what form of IBD do you see non caseating granulomas

Answer 29

crohns

Question 30

when is PSA repeated if high

Answer 30

2 weeks

Question 31

what histopathological description is given to cells that have lost their intercellular connections between neighbouring cells

Answer 31

acantholysis

Question 32

what monoclonal antibody therapy targets human epidermal growth factor receptor 2 and is used in the treatment of breast cancer

Answer 32

transtuzumab

Question 33

what protein is defective in PCKD

Answer 33

polycystin 1

Question 34

most common type of renal cancer

Answer 34

renal cell carcinoma

Question 35

acute rheumatic fever diagnostic criteria

Answer 35

jones

Question 36

HOCM inheritance

Answer 36

autosomal dominant

Question 37

nail sign in graves disease

Answer 37

thyroid acropachy

Question 38

what does alpha 1 antitripsin inhibit and what are the effects of this

Answer 38

neutrophil elastase prevents emphysema

Question 39

how does pagets disease present

Answer 39

eczema of the nipple then the areola

Question 40

positive courvoisiers sign is due to what cancer

Answer 40

pancreatic

Question 41

muddy brown casts

Answer 41

acute tubular necrosis

Question 42

what bladder cancer is associated with chronic cystitis

Answer 42

squamous cell carcinoma

Question 43

what protein is low in wilsons

Answer 43

caeruloplasmin

Question 44

alpha 1 antitripsin deficiency presentation

Answer 44

obstructive on spirometry lower FEV1 hyperinflation on cxr productive cough SOB on exertion

Question 45

epithelial cell casts in urine

Answer 45

acute tubular necrosis

Question 46

white cell casts in urine with eosinophilia and recent antibiotic use

Answer 46

acute interstitial nephritis

Question 47

what malignancy is lambert eaton myasthenic syndrome associated with

Answer 47

small cell lung cancer

Question 48

what paraneoplastic syndrome is most associated with small cell lung cancer

Answer 48

SIADH

Question 49

what infection to rule out before giving infliximab

Answer 49

tuberculossi

Question 50

how does eosinophilic granulomatosis with polyangitis manifest

Answer 50

sinus problems recurrent infections progresses to severe asthma

Question 51

crest syndrome also known as

Answer 51

limited cutaneous systemic sclerosis

Question 52

taco full form

Answer 52

transfusion associated circulatory overload

Question 53

malt lymphoma full form

Answer 53

mucosal associated lymphoid tissue lymphoma

Question 54

eatl full form

Answer 54

enteropathy associated t cell lymphoma

Question 55

most abundant cell in peripheral blood

Answer 55

neutrophil