HISTO Flashcards
beady fibrous vegetations (verrucae)
acute rheumatic fever
aschoff bodies (small giant cell granulomas)
acute rheumatic fever
anitschkov myocytes (regenerating myocytes)
acute rheumatic fever
whirls of shed epithelium- curschmann spirals
asthma
charcot leyden crystals
asthma
AR mutation/ F508 del
CF
ground glass/honeycomb appearance of lungs on CT CAP
interstitial lung disease
interstitial pneumonitis
atypical pneumonia
rust coloured sputum in context of pneumonia
streptococcus pneumoniae
what are the 4 stages of lobar pneumonia
- consolidation
- red hepatisation-neutrophilia
- grey hepatisation- fibrosis
- resolution
what lung cancer is associated with paraneoplastic syndrome secreting PTHrp?
squamous cell carcinoma
what lung cancer has the strongest association with smoking?
squamous cell carcinoma
oat cells
small cell lung cancer
what lung cancer is associated with paraneoplastic syndrome secreting ADH (SIADH) and ACTH (cushings)?
small call
whats the most important prognostic factor in lung cancer?
staging
where does mesothelioma arise from?
parietal or visceral pleura
iron laden macrophages
pulmonary oedema
white out of lung fields
diffuse airway disease eg ARDS
signet ring cells in a ovarian tumor
krukenbergs tumor
skip lesions
crohns
cobblestone appearance
crohns
non caseating granuloma
sarcoidosis
crohns
apthous ulcer
crohns
rosethorn ulcer
crohns
caseating granuloma
TB
backwash ilietis
UC
smoking is protective
ovarian cancer
UC
pseudopolyps
UC
5-ASA
UC
name a 5-ASA
mesalazine
4 cs of c diff
ciprofloxacin
cephalosporins
clindamycin
coamox
porcelain gallbladder
chronic cholecystitis
what does liver make
fatty acids
amino acids
glucose
albumin
fibrinogen
clotting factors
oestrogen
glucocorticoids
bile
how much bile does liver make daily
600-1000ml
what does liver metabolise
drugs
insulin
GH
PTH
what does liver store
glycogen
vitamins ADEK some B12
folate
iron
copper
liver phagocytes
kuppfer cells
what cells in liver make fibrinogen?
stellate
where in liver are stellate cells found
space of disse
spotty necrosis
acute hepatitis
piecemeal necrosis
chronic hepatitis
cirrhotic liver
hepatocyte necrosis
fibrosis
nodular regeneration
disturbance of vascular architecture
haemochromotosis gene and chr
HFE gene
chr 6
wilsons gene and chr
ATP7B gene
chr 13
size of macro vs micro nodular hepatic cirrhosis
micro= nodules <3mm
macro= nodules >3mm
major causes of cirrhosis
alcohol liver disease
NAFLD
chronic viral hep (b and c)
score used for hepatic cirrhosis severity
child pugh
components of child pugh score
albumin
PT
encephalopathy
ascites
bilirubin
steatosis
fat droplets in heaptocytes- fatty liver
hepatocyte balooning
alcoholic hepatitis
mallory denk bodies
alcoholic hepatitis
micronodular cirrhosis in liver
alcoholic cirrhosis
autoimmune hepatitis cells
plasma cells
antibodies for type 1 autoimmine hep
ANA
anti smooth muscle
antibodies for type 2 autoimmine hep
anti LKG Ig
structure affected in PBC
intrahepatic bile ducts
structure affected in PSC
extra and intrahepatic bile ducts
anti mitochondrial antibodies
PBC
bile duct loss with granulomas
PBC
pANCA
PSC
PSC assoc w what condition
IBD
bile duct dilatation US
PSC
ERCP beading of bile ducts
PSC
onion skinning fibrosis
PSC
what condition increases risk of cholangiocarcinoma
PSC
inheritance pattern of haemochromatosis
autosomal recessive
inheritance pattern of wilsons
autosomal recessive
inheritance pattern of alpha 1 antitripsin
autosomal dominant
haemochromatosis stain
prussian blue
wilsons stain
rhodanine- copper
alpha 1 antitripsin stain
periodic acid schiff- intracytoplasmic globules of A1AT
kayser fleischer rings
wilsons
haemochromatosis mx
venesection
desferrioxamine
wilsons mx
penicillamine
alfatoxin B1
hepatocellular carcinoma
most common liver tumor
secondary met
cholangiocarcinoma type of cancer
adenocarcinoma
marker for hepatocellcular carcinoma
alpha fetoprotein
liver cancer assoc w OCP
benign hepatic adenoma
scoring system for prostate cancer
gleason
most common type of urinary stone
calcium oxalate
most common form of prostate cancer
adenocarcinoma
most common renal malignancy
renal call carcinoma
frond like growths
renal transitional cell carcinoma
childhood renal tumor
wilms tumor/nephroblastoma
most common bladder tumor
transitional cell tumor
renal electron mircroscopy: loss of podocyte foot processes, immunofluoresence nothing
minimal change disease
focal segmental glomerulosclerosis
renal electron mircroscopy: loss of podocyte foot processes, immunofluoresence immune complex deposition all along GBM
membranous glomerulonephropathy
kimmelstiel wilson nodules
diabetes mellitus nephropathy
pancreatic tumor mx
whipples to resent
folfirinox chemo pall
portal triad
bile duct
hepatic artery
hepatic portal vein
liver enzyme raised in MI
aspartate aminotransferase
anti GBM antibodies
good pastures syndrome
type 1 cresenteric glomerulonephropathy
nephritic syndrome
wegeners granulomatosis
cANCA
type 3 cresenteric glomerulonephropathy
nephritic syndrome
microscopic polyangitis
pANCA
type 3 cresenteric glomerulonephropathy
nephritic syndrome
alport syndrome
type IV collagen 5 alpha chain mutation
x linked
nephritic syndrome
sensorineural deafness
eye disorders
organism commonly causing pyelonephritis
e coli
location of thrombi in HUS vs TTP
HUS= only kidneys
TTP= systemic
HUS traid
MAHA
thrombocytopenia
renal failure
TTP pentad
MAHA
thrombocytopenia
renal failure
fever
neurological sx
coombs test and blood film in HUS/TTP
coombs test negative (not autoimmune)
film= shistocytes
gene associated with TTP and its effect
ADAMTS13
usually cleaves vWF so lack of this= clots
illness before HUS
e coli diarrhoea in kids
renal causes of acute renal failure
acute tubular necrosis (most common)
acute glomerulonephritis
thrombotic microangiopathy
CKD GFR stages
5= >90
4= 60-89
3= 30-59
4= 15-29
5= <15 or on renal replacement therapy
most common cause of CKD in UK
diabetes
wire loop capillaries, complement deposition in lumpy bumpy granular deposits
lupus nephritis
waxy casts in urine
CKD
thick basement membrane with spike and dome appearance
membranous glomerulonephritis
inheritance pattern of benign familial haematuria
autosomal dominant
violin string peri hepatic inflammation
fitz hugh curtis
powder burns
endometriosis
chocolate cysts
endometriomas in endometriosis
uterus in adenomyosis
bulky and globular
where does endometrial tissue grow in adenomyosis
myometrium
types of fibroid
subserosal
submucosal
intramural
2 categories of endometrial cancer and how they differ
endometriod= oestrogen dependant
non endometriod= non oestrogen dependant
most common type of ovarian cancer
epithelial
ovarian cancer epithelial cells and psamomma bodies
epithelial benign serous cystadenoma
pseudomyxoma peritonei
appendicitis tumor that migrates to ovaries, epithelial benign mucinous cystadenoma
ovarian cancer tubular glands
epithelial malignant endometriod
ovarian cancer clear cells, clear glands, hobnail appearance
epithelial malignant clear cell
ovarian cancer call exner bodies
sex cord granulose/theca cell
ovarian cancer meigs syndrome
sex cord fibroma
ovarian cancer mucin producing signet ring cells
krukenbergs tumor
FIGO staging endometrial cancer
1= confined to uterus
2= spread to cervix
3= spread to pelvis
4= spread to bladder/bowel/distant
FIGO staging ovarian cancer
1= confined to ovary
2= confined to pelvis
3= confined to abdomen
4= mets past abdomen
ovarian cyst common in pregnancy
corpus luteal
most common ovarian cyst
follicular
cervix covered by what cells
squamous epitheium