Medecine Individuals Own Knowledge Flashcards

1
Q

Pasteur competition with who, when and where

A

1854
Pouches
French Academy of Sciences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Germ theory vs…..

A

Spontaneous generation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Where did Pasteur find germs and what were there responsible for

A

Beer milk, silk

Responsible for it going off

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How did Pasteur kill germs

A

Boiling (pasteurisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Vaccines Pasteur developed

A

Anthrax

Chicken cholera

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Trial for anthrax vaccine

A

24 test sheep, 24 control sheep, waited 30 days after inoculation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Boy Pasteur tested on

A

Joseph Miester, bitten 15 times by rabid dog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lister main antiseptic

A

Carbolic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Why was carbolic acid unpopular

A

Cracked surgeons hands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Case study for how refectory antiseptics where

A

11 year old James greenness 1865, leg run over by a cart, dressed compound fracture of the tibia with lint soaked in carbolic acid, leg healed in 6 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Effect of antiseptics on hospitals

A

Newcastle infirmary, 6:10 died to 1/10 died

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Other techniques which reduced infection

A

Pares ligatures, sterilised cat gut

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ae septic surgery aim

A

Make whole room germ free

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Aseptic surgery methods

A

1887 all instruments steam sterilised

1894 sterilised rubber gloves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Koch methods of indentifying bacteria

A

Agar jelly
Perry dish
Use of dyes such as eosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Bacteria Koch identified

A

Bacillus anthracis
Bacteria responsible for septicimia
Vibrio cholerae later

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How did Koch discover the source of cholera

A

Egypt and Nile crocodiles
India
Isolated vibrio cholerae from wells

18
Q

Koch application of his knowledge

A

Called back to Germany due to outbreak

Introduced clean water supplied ending the epidemic

19
Q

Ehrlich aims

A

Discover magic bullets for diseases, methods of killing a specific microbe without damaging useful microbes

20
Q

Ehlichs 20th century paper

A

‘Chemotherapy, killing of specific cells

21
Q

Eherlichs work on syphillis

A

Isolated stphillis1896
Aimed to find its magic bullet
Compounds of arsenic
Salvarson 606 606th compound he tried

22
Q

Other magic bullets

A

Sulphonamides from tar compounds

23
Q

Significance of the magic bullets

A

First chemical cures, first available mass medecine

24
Q

Flemings initial investigations

A

Lysomne in tears discovered its antiseptic properties
Not always successful
Abandoned idea

25
Flemming discovwry of penicillin
Summer 1938 left out Petri dishes Found s mound which no bacteria grew near Spores blew through open window Couldn't investigate further due to lack of funding
26
Florey and chain further penicillin research
1939 team of Oxford researchers
27
Experiments with penicillin
8 mice, 4 controls injected with deadly bacteria only 4 died
28
Human tests
19th Feb 1941, first human subject lab ran out of supplies and he died 2 more patients successfully treated August 1942 Fleming treats friend with meningitis
29
Mass production of penicillin
1941, Florey goes to America to show drug companies 1942 80 million USD loan to 4 companies 1943 production began used in North Africa 1945 2,000,000 doses used per month 13/15% of wounded would have died without it Halved time soils urea spent in hospital
30
Discovery of chloroform
Nitrous oxides or ether used Dimpson experimenting with different chemicals with Doctors Kieth and Duncan "Under the table in minutes" Then tested on his niece Miss Peterie
31
Issues with chloroform
Dosage one girl died from od while removing a toenail Religious objections, "with painful labour you will give birth to children" part of Eve's punishment Didn't reduce fatality rates as more complex and longer operations
32
How did chloroform become popular
Queens 8th Child, used "that blessed chloroform"
33
Nightingale work at Scutari
``` 300 scrubbing brushed 38 nurses "General dealer" Rebuilt part of the hospital Death rate falls from 42% to 2% Royal army medical corps 1898 ```
34
Nightingale publishing ideas
``` 200 leaflets and phamphlets "Notes on Nursing "1859 Statistics, "the most important science in the world" Notes on hospitals 1863 Specification and greAt ormond street Nursing school 1860 ```
35
Garret Anderson struggle to qualify
1858 medical act only practise if on medical register but needed to graduate Wichita was impossible for women Rejected by Edinburgh and St. Andrews 1865 passed apothecaries exam but prevented from gtaduating Qualified in Paris and put onto the register 1869 1876 act passed allowing women to qualify
36
Garret Anderson inspiration to others
Elizabeth Hogsn 1870 Sophia Jex Blake set up medical school for women 23 educated in first year, recognised in 1877 by London free hospital 318 enrolled 1903 1912 212 women on the register 1871 new hospital for women run by women for women
37
John snow investigation of cholera in the broad street area
1854 epidemic killed 20,000 700 deaths in 10 days Plotted deaths on street map Incidences highest where people drew water from pump Water carried in bottle across London infected people elsewhere Removed the handle
38
John snow proof cholera was waterborne
Two seperate water companies Upstream and filtered vs downstream not filtered 13 times more likely to get cholera Disproved miasma
39
Chadwick initial investigation
1839 report in the sanitary conditions of the labouring poor of Great Britain Varied hugely with class Called for end of laissez fairs Health not the responsibility of the individual
40
Chad wicks envy emery in the public health act
Further 60,000 die of cholera Local boards of health set up to monitor sewers drainage ect Provided medical officers to "inspect nuisances