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(NEW) PSMA > MED ORG I > Flashcards

MED ORG I Flashcards

1
Q

-Ch’ang shang, ma huang

A

Shen Nung

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2
Q

-Chaulmoogra fruit

A

American Indians

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3
Q

-Ipecacuanha root

A

Brazil

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4
Q

-Coca leaves

A

South American Indians

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5
Q

-opium, squill, hyoscyamus,
viper toxin

A

Greek Apothecary

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6
Q

Cu, Zn ores, Fe
sulfate, Cadmium oxide

A

Greek Apothecary

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7
Q

Basic studies of chemistry and physics
shifted from Greco-Roman to _____

A

Arabian
Alchemy

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8
Q

Paracelsus glorified ___ as cure-all in the
belief that chemical could cure diseases

A

Sb

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9
Q

19th Century aka

A

Age of Innovation and Chemistry

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10
Q

extracted morphine from poppy

A

Friedrich Sertürner

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11
Q

his unproven principle
“similia similibus curantur”

A

Samuel Hahnemann

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12
Q

– isolated emetine from Ipecacuanha

A

Pierre-Pelletier

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13
Q

acetic acid synthesis

A

Adolph Kolbe

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14
Q

concept of biological
receptor

A

British pharmacologist John

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15
Q

First alkaloid synthesis –

A

Coniine

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16
Q

sidechain theory

A

Paul Ehrlich

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17
Q

Mass production of Quinine Sulfate was in ___ factory

A

Pelletier Factory

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18
Q

Coniine is isolated from ____

A

Hemlock

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19
Q

Only Liquid Alkaloid

A

Coniine

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20
Q

Aspirin was discovered by

A

Felix Hoffman

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21
Q

20th Century aka

A

Rise of Synthetic Chemotherapeutic Agents

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22
Q

discovered Penciliin

A

Alexander Fleming

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23
Q

Prontosil / Sulfamidochrysoidine

A

Gerhard Domagk

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24
Q

-single most important
breakthrough in psychiatric
treatment

A

Chlorpromazine

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25
Q

-antidepressant

A

Iproniazid

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26
Q

-first dibenzazepine

A

Imipramine

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27
Q

-first commercially successful
SSRI

A

Fluoxetine

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28
Q

discovered Oxytocin

A

Henry Dale

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29
Q

discovered Thyroxine

A

Edward Kendall

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30
Q

discovered Insulin (2)

A

Frederick Banting & Charles Best

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31
Q

Russel Marker converted Diosgenin to

A

Progesterone

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32
Q

discovered Noerthindrone

A

Carl Djerassi

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33
Q

discovered Progesterone + Noerthindrone

A

John Rock

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34
Q

Abortion Pill

A

Mifepristone

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35
Q

Morning-After Pill

A

Mifepristone + Misoprostol

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36
Q

-dentist who administered Nitrous
oxide during tooth extraction

A

Horace Wells

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37
Q

-used ether as an anesthetic agent

A

Crawford Long

38
Q

-gave the first successful public
demonstration of surgical anesthesia
(1846)

A

William Morton

39
Q

-used as anesthetic agent at St.
Bartholomew’s Hospital

A

Chloroform

40
Q
  • Induces sleep
A

Laudanum

41
Q

synthesized 5,5-diethylbarbituric acid

A

Adolph Von Beyer

42
Q

Developed due to modification of
the barbituric acid molecule

A

Hydantoins

43
Q

Company that introduced Phenobarbital

A

Bayer Pharm’l Company

44
Q

isolated cocaine

A

Albert Niemann

45
Q

-First to use cocaine for topical
anesthesia in ophthalmological
surgery

A

Carl Koller

46
Q

-determined the structure of cocaine
and atropine

A

Richard Willstater

47
Q

-structural analogs of cocaine (4)

A

Benzocaine, procaine, tetracaine and
lidocaine

48
Q

Humulin is produced by

A

Eli Lilly

49
Q

1st genetically engineered insulin approved by the FDA

A

Humulin

50
Q

First orally active contraceptive

A

Noerthindrone

51
Q

morning-after pill AKA

A

Plan B

52
Q

Cocaine is isolated from

A

Erythroxylum coca

53
Q

Which is Lipid Soluble? Digoxin or Digitoxin

A

DIGITOXIN

54
Q

William Withering discovered _____ was
beneficial to those suffering from abnormal fluid
buildup

A

Digitalis purpurea

55
Q

E. Humolle and T. Quevenne isolated

A

Digitoxin

56
Q

discovered the first anticholesterol drug

A

Akira Endo

57
Q

discovered Lovastatin

A

Merck

58
Q

isolated digoxin

A

Sydney Smith

59
Q

-used for leukemia therapy (2)

A

Sulfur mustard and nitrogen mustard

60
Q

-first effective for leukemia, discovered by George
Hitchings and Gertrude Elion

A

6-mercaptopurine

61
Q

Gold Standard for Cancer

A

CISPLATIN

62
Q

2nd Best for Cancer

A

CARBOPLATIN

63
Q

discovered by Moeroe Wall and
Masukh Wani

A

PACLITAXEL

64
Q

Paclitaxel is isolated from

A

Pacific Yew Tree - Taxus brevifolia

65
Q

A scientific discipline at the intersection
of chemistry and pharmacy involved with
designing, synthesizing and developing
pharmaceutical drugs.

A

Organic
Pharmaceutical
Chemistry

66
Q

It also includes the study of existing
drugs, their biological properties, and
their Quantitative Structure-Activity
Relationships(QSAR).

A

Organic
Pharmaceutical
Chemistry

67
Q

Involves the identification, synthesis and
development of new chemical entities
suitable for therapeutic use.

A

Medicinal
Chemistry

68
Q

Focused on quality aspects of medicines
and aims to assure fitness for the
purpose of medicinal products

A

Pharmaceutical
Chemistry

69
Q

is a strategy of the essential importance for chemistry and
pharmacy, based on the idea that when we change a
structure of a molecule then also the activity or property of
the substance will be modified.

A

Quantitative Structure-Activity
Relationships (QSAR)

70
Q

– including a clinical condition and treated with the test drug

A

In Vivo

71
Q

drug activity is tested on isolated tissues or cells

A

In Vitro

72
Q

compound showing a desired pharmacological property which can be used
to initiate a medicinal chemistry project

A

LEAD COMPOUND

73
Q

Enzyme (In Vitro or In Vivo)

A

IN VITRO

74
Q

Drug discovered thru Serendipity

A

PENICILLIN

75
Q

NMR meaning

A

Nuclear Magnetic Resonance

76
Q

Specific Compound AKA

A

Pharmacopore

77
Q

the science of the properties of the drugs and its
effects in the body

A

PHARMACOLOGY

78
Q

the study of the interaction of drugs with cells

A

PHARMACODYNAMICS

79
Q

the handling of a drug within the body, it includes
the ADME processes

A

PHARMACOKINETICS

80
Q

in vitro and in vivo testing

A

Toxicity Testing

81
Q

determination of LD 50

A

Toxicity Testing

82
Q

the general area of study concerned with the
formulation, manufacturing, stability and
effectiveness of a pharmaceutical dosage form

A

Pharmaceutics

83
Q

Filed before drug may be given to human (clinical trials)

A

IND

84
Q

submitted for review and approval after the
completion of the clinical trials and requirements have
been met.

A

NDA

85
Q

– Abbreviated NDA (Generic Drug)

A

ANDA

86
Q

Foreign Compounds aka

A

Xenobiotics

87
Q

main site of metabolism and detoxification of
endo/exogenous compounds

A

LIVER

88
Q

– pass thru the liver before being further distributed
in body compartments

A

PO drugs

89
Q

Metabolism before reaching systemic circulation

A

First-Pass Effect

90
Q

– Limit the BA of orally administered drugs

A

First-Pass Effect

91
Q

principal psychoactive compound in marijuana

A

THC

(NEW) PSMA (10 decks)

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