Mechanisms Pavlovian conditioning

Question 1

Lomo (1966)

Answer 1

Electrical stimulation Perforant path
Causes LT increase in magnitude EPSP
Needs pulses close together
Accumalation effect

Question 2

Kelso (1986)

Answer 2

For LTP need:
1, Depolarise CA1 neuron
2, Stimulate afferent axons
3, Strengthen synapse

Question 3

Collingridge (1983)

Answer 3

AP5 blocks NMDA receptor

blocks LTP in dose dependent manner

Question 4

Shi (1999)

Answer 4

inserted AMPA into rat hippocampus
Flouride trace At start base dendritic spine
After LTP goes to tip of synapse
Blocked by AP-5

Question 5

Frey (1998)

Answer 5

Blocked protein synthesis
LTP normal but dissapeared after few hours
Suggests something shortly after causes LTP

Question 6

Carew (1989)

Answer 6

Sea slug

When sensory neuron activated with motor neuron gives bigger response

Question 7

Hawkins (1983)

Answer 7

Sensory neuron followed by tail shock increases ability to excite motor neuron

Question 8

Bliss and Lomo (1973)

Answer 8

LTP can last several months

Question 9

Lynch (1984)

Answer 9

NMDA essential in controlling calcium ions for LTP