Drug Counter adaption Flashcards
Self and Nessler (1998)
Exposure to cues may be big in drug maintenance and relapse
Robinson (1993)
LT drug increases DA release to NAc
Kleven (1990)
Drugs alter DA levels in NAc
Henry (1998)
Cocaine withdrawal
spontaneous increase VTA then decrease
Weiss (1992)
DA decreases NAc with withdrawal
Rassinck (1993)
CRF associated withdrawal
Koob (2004)
Drug withdrawal increases brain reward threshold
Ahmed and Koob (1998)
Allowed S-A access to cocaine 6 hours a day and led to progressive escalation
Ahmed (2002)
Reward threshold 6 hour group progressively increased
Koob (1992)
Different brain areas mediate physical and mental symptoms of dependence
Koob and LeMoal (2008)
Reward set points differ in users and non-users