Mechanisms of Oncogenesis Flashcards
Define cancer and tumour
Describe the multi-stage process of cancer
What are driver and passenger mutations
What are the 5 areas that can be targeted for specific mutations?
Describe how cancer can be described as cancer of the genome
What is the difference between the traditional vs modern view of cancer?
ie describe the difference between chemo and modern therapy
Primary treatment: chemo inhibits DNA replication, disrupt microtubule function in rapidly dividing cells inc tumours
Now we use our knowledge of different tumours to give targeted treatments based on their molecular profile
What are the main types of carcinogens and examples of them?
How can chemical carcinogens cause cancer and how can this be treated?
How can ionising radiation (eg XR) and non-ionising radiation (eg UV) cause cancer?
How can viruses cause cancer?
3 Hereditary cancer predisposition syndromes?
What are 7 ways to cut down cancer?
