Mechanism of Action of B receptor drugs

Question 1

List the drugs inducing vasoconstriction

Answer 1

sympathomimetics (noradrenaline, adrenaline, direct alpha 1 mimetics (phenylephrine, midodrine, naphazoline), indirect sympathomimetics (hydroxyamphetamine) SYMPATHOMIMETICS ARE USED FOR HYPOTENSION, SHOCK THERAPY, DECONGESTION)
- Triptans and ergot alkaloids are used in migraines

Question 2

list the drugs inducing vasodilation

Answer 2

• blockers of alpha 1 selective (doxazosine, terazosine), and CNS acting drug blockers (alpha 2 mimetics like methldopa)
  ACEi, ARB, renin inhibitors
  endothelin antagonists for pulmonary HTN

Question 3

direct vasodilators are

Answer 3

CCB, K channel activators (levosimendan, minoxidil), hydralazine, NO donor, PDE-1 (ending in -fil), soluble guanylatecyclase activators

Question 4

what vasodilator is used for erectile dysfunction

Answer 4

phosphodiesterase five inhibitors

Question 5

list the non selective B blockers

Answer 5

propanolol, sotolol, timolol, pindolol

Question 6

list the selective beta 1 blockers

Answer 6

atenolol, betaxolol, metoprolol, bisoprolol, esmolol, acebutolol

Question 7

list drugs with combined BB effects

Answer 7

celiprolol, labetolol, carvedilol