Anti-platelet Drugs

Question 1

list anti-platelet drugs (6)

Answer 1

aspirin
ticlodipine
cilostazol
dipyridamole
Abciximab
thienopyridines

Question 2

how does aspirin work?

Answer 2

it irreversibly acetylates COX1/COX2 which therfore decreases synthesis of thromboxane

Question 3

name an ADP receptor inhibitor and its side effects

Answer 3

ticlodipine. Can cause neutropenia, fatal agranulocytosis with thrombocytopenia

Question 4

name 2 PDE inhibitors

Answer 4

cilostazol and dipyridamole.

Question 5

explain how PDE inhibitors work

Answer 5

inhibition of PDE = increase cAMP in platelets = increase PKA = impaired platelet aggregation and formation of the platelet plug. NOTE INCREASE CAMP CAUSES ARTERIOLAR VASODILATION WHICH TREATS CLAUDICATION IN PATIENTS WITH PAD

Question 6

name 3 GP2b/3a inhibitors

Answer 6

abciximab, eptifibatide, tirofiban prevent platelet aggregation and plug formation. It can cause drug induced thrombocytopenia

Question 7

explain how thienopyridines work

Answer 7

they irreversibly bind to P2Y12 ADP receptor, which prevents aggregation of platelets. Eg. clopidogrel, ticagrelor, prasugrel. They are used for CAD, acute ischemic stroke, MI, decrease peripheral artery disease risk