Mechanism of Action of Anti-HTN

Question 1

how does one calculate BP

Answer 1

BP=CO*SVR

Question 2

the drugs for HTN can affect 2 properties which are?

Answer 2

CO and SVR

Question 3

list the drugs affecting CO

Answer 3

CCB (non-DHP), and B blockers, diuretics, drugs affecting RAAS

Question 4

list the drugs affecting SVR

Answer 4

alpha blockers, drugs affecting RAAS, DHP, K channel activating drugs, hydralazine, nitrates, nitroprusside

Question 5

list the 5 drug types you would give to treat initial monotherapy of HTN

Answer 5

diuretics, B blockers, ACEi, ARB, DHP

Question 6

how do DHP affect HTN?

Answer 6

they block L type Ca channels, which dont allow contraction and therefore the vessel cannot constrict

Question 7

what drugs do you give for a HTN emergency

Answer 7

NO donors (nitroglycerin, nitroprusside), urapidil, b blockers, ACEi

Question 8

how do thiazides cause hypokalemia

Answer 8

in 2 ways:

(1) By inhibiting the NaCl symporter at the DCT they cause an increase in Na [] reaching the CT. This causes increase in activity of the Na/K ATPase and causes excretion of K
(2) Thiazides will reduce total volume in the blood eventually, this will cause renin secretion, which activates aldosterone, which increases Na/K ATPase activity once more