MDMA

Question 1

What are the medical indications of MDMA? (2)

Answer 1

PTSD, when adminsitered 3 times improvements can still be present 6 years post treatment

anti-depressants that works similiar to SSRIs and SNRIs

Question 2

What are the psychological effects of MDMA? (3)

Answer 2

euphoria

loss of inhibitions

energy surge

Question 3

What are the NTs used by MDMA and which is the main one? (3)

Answer 3

5-HT - main

DA

NA

Question 4

What are the main physiologically negative effects that arise from MDMA use? (3)

Answer 4

acute hyperthermia - can lead to muscle damage and renal failure

increase water intake and retention - increased ADH release causing thirst, increased hydration and hyponatraemia

heart failure - if undiagnosed pre-use

Question 5

What are the signs and consequences of excessive water intake? (2)

Answer 5

symptoms are dizziness and disorientation before

collapsing into a coma and then death

Question 6

What are the chronic effects of MDMA? (2)

Answer 6

long term deleted memory

decreased cognitive function

Question 7

Explain the pharmacology of ecstasy (4)

Answer 7

Taken up by SERT transporter

inhibits VMAT1/2 leading to a build up in cytosol

MDMA activates TAAR1 which results in the transporter removal or reversal

more MDMA ends up in the synaptic cleft