Barbiturates

Question 1

Effects of barbiturates (2)

Answer 1

positive allosteric modulators, increase GABA affinity

other actions at high doses since they’re dirty compounds

Question 2

Receptor mechanism of barbiturates (6)

Answer 2

increase GABAa channel directly

other glycine receptor activation

block NAchR

block 5-HT3

block AMPA/kainate

blockade of Ca dependent NT release

Question 3

Barbiturates and OD (1)

Answer 3

must be particularly careful since there is no antidote

Question 4

What 3 drugs are used in lethal injection (3)

Answer 4

Sodium Thiopental

Pancuronium Bromide

Potassium Chloride

Question 5

Sodium Thiopental mechanism (2)

Answer 5

goes to the heart and is circulated around the whole body

induces sleep

Question 6

Pancuronium Bromide mechanism (2)

Answer 6

muscle relaxant

effects teh diaphragm and lungs

Question 7

Potassium Chloride mechanism (2)

Answer 7

prevents heart from beating through

hyperpolarisation

Question 8

What are the receptors and effects of GHB? (5)

Answer 8

Pro drug is GBL

effects GABAb and GHB receptors

used as a date-rape drug

in low concentration it effects GHBr which are stimulatory by increasing dopamine

in high concentrations it effects are sedative as they decrease dopamine via the GABAb receptor