MCM 2-27 Intro to Hepatitis Viruses Flashcards
the hepatitis viruses are closely related to each other TF
false
why are the symptoms of hepatitis viral infections similar?
they all infect hepatocytes. All can cause acute hepatitis, treated with supported care
All of the heptitis viruses can cause what? How do you treat it?
acute hepatitis - treat with supportive care
Which hepatitis viruses have a vaccine?
only A and B have vaccines
how are the hepatitis viruses transmitted?
a = fecal oral
B&C are birth/sex/blood transmitted
diagnosis of hepatitisviruses
by serology
Hep A - IgM = acute, IgG = recov/vaccinated
Hep B - Viral surface antigen = acute, IgG against viral surface antigen = recovered/vaccinated
Hep C - EIA = real or false positive, confirm with RIBA
________ can cause chronic hepatitis leading to cirrhosis and/or cancer.
Treatments?
B and C
Polymerase inhibitors + IFN = many side effects, ineffective
second gen protease inhibitors good for type 1, have own side effects
Third gen antivirals (2014) show amazing results but very expensive
why do patients look towards alternative medicine? should we care?
grueling treatment and uncertain prognosis for second gen-treatment for chronic hep B and C (and very high cost of third gen) causes patients to look towards alternative medicine
its important to know what the patient is taking to check for interactions with the western medicine you have prescribed
______produces a lot of non infective “decoy” particles that preoccupies the antibodies
Hep-B
Traveling to _____ is a red flag for ______
Egypt, Hep C
_________ can cause extra-hepatic diseases
antibody/antigen deposition diseases. Lots of decoy protein, huge amount of antibody in blood, some of these complexes get stuck in small blood vascularture (kindney and joints)
problem with IV interferon?
normally interferon gets released locally around the infection to reduce synthesis
with IV, it gets into every cell
