March '22

Question 1

which gastric hormone is hypersecreted, resulting in PUD and pruritus, a common complication of polycythemia vera?

Answer 1

histamine

Question 2

tx of minor bleeding in hemophilia A?

Answer 2

topical thrombin

Question 3

what test will be abnormal in hemophilia B?

Answer 3

a PTT

Question 4

what side effect can patient’s with hemophilia B and inhibitors experience if given factor replacement?

Answer 4

anaphylaxis

Question 5

when does the nadir in the absolute neutrophil count occur after the completion of a chemotherapy session?

Answer 5

5-14 days

Question 6

MCC of drug induced neutropenia in children?

Answer 6

due to abx - macrolides, cephalosporins, and penicillins

Question 7

hyperdense lines at the metaphyses in young children on knee and wrist XR

Answer 7

lead lines - chronic lead poisoning

Question 8

when are hypersegmented neutrophils seen?

Answer 8

multiple forms of megaloblastic anemia such as alcohol use, folate deficiency, and vitamin B12 deficiency

Question 9

microcytic, hypochromic anemia in patient of mediterranean descent

Answer 9

thalassemia

Question 10

crew cut skull XR, chipmunk facies

Answer 10

beta thalassemia major

Question 11

antibiotic best known for causing aplastic anemia

Answer 11

chloramphenicol

Question 12

stable patient getting hives and pruritis shortly after starting blood transfusion - treatment?

Answer 12

continue transfusion - give antihistamine as this is likely allergic reaction, unlikely IgA deficiency

Question 13

Labs of DIC

Answer 13

high PT, PTT, thrombin clotting time

low platelets, fibrinogen

Question 14

acute GI bleed and pt on warfarin - next step?

Answer 14

Vit K IV, + FFP

Question 15

MC gram negative pathogen identified in neutropenic fever?

Answer 15

pseudomonas

Question 16

what are the components of cryoprecipitate?

Answer 16

Factors VIII and XIII, vWF, fibrinogen, and fibronectin

Question 17

lab findings of pleural effusions associated with rheumatoid arthritis

Answer 17

low glucose, low pH, and high LDH

Question 18

serum blood test that helps determine the degree of hemolysis

Answer 18

haptoglobin

Question 19

electrolyte imbalances caused by blood transfusions

Answer 19

hypocalcemia - citrate, an anticoag in RBCs binds serum calcium
hyperK or hypoK

Question 20

classic chest XR findings seen in sarcoidosis?

Answer 20

bilateral hilar and paratracheal adenopathy

Question 21

T cell activation such as in contact dermatitis is what hypersensitivity reaction?

Answer 21

type IV - delayed cell mediated

Question 22

what skin condition can be accompanied by oil spots on the nails?

Answer 22

psoriasis

Question 23

factors contained in 4 factor prothrombin complex concentrate?

Answer 23

factors II, VII, IX, and X in addition to protein C and S

Question 24

beta thalassemia major is associated with what other condition?

Answer 24

cholelithiasis

Question 25

positive direct antiglobulin testing is concerning for

Answer 25

hemolytic transfusion reaction

Question 26

diagnosis of acute chest syndrome requires

Answer 26

XR evidence of a consolidation plus fever or respiratory findings

Question 27

MC infectious organism that is also a trigger for SJS and TEN?

Answer 27

mycoplasma pneumonia

Question 28

what leukemia puts patients at highest risk for severe complications from hyperleukocytosis?

Answer 28

AML

Question 29

MC risk factor for new onset childhood immune thrombocytopenia?

Answer 29

viral infection

Question 30

emergent reversal of dabigatran?

Answer 30

idarucizumab

Question 31

risk factors for polyarteritis nodosa?

Answer 31

recent hep B or C infection, IV drug use

Question 32

treatment of polyarteritis nodosa?

Answer 32

glucocorticoids, such as prednisone, more severe cases need cyclophosphamide
if concerning for viral hepatitis, antivirals are first line therapy

Question 32

treatment of polyarteritis nodosa?

Answer 32

glucocorticoids, such as prednisone, more severe cases need cyclophosphamide
if concerning for viral hepatitis, antivirals are first line therapy

Question 33

RDW in Fe deficiency anemia?

Answer 33

high

Question 34

elevated serum ACE level found in what?

Answer 34

sarcoidosis - noncaseating granulomas with the lung being the most commonly affected organ

Question 35

drug most associated with aplastic anemia?

Answer 35

phenytoin

Question 36

subtype of endocarditis associated with SLE?

Answer 36

libman sacks endocarditis - aseptic verrucous thrombi on heart valves

Question 37

MC immunoglobulin found in multiple myeloma?

Answer 37

IgG

Question 38

disorder associated with purpura fulminans?

Answer 38

inherited or acquired protein C deficiency

Question 39

differentiate TTP and DIC with labs

Answer 39

Pt with TTP will have normal coagulation studies, DIC will have abnormal