Manic Depression Drugs

Question 1

Available as citrate and CO3 salts

Anti-manic agents

Prophylaxis and treatment of bipolar disorder

Toxicity : from single toxic dose or
prolonged use

Renal toxicity and hypothyroidism

Answer 1

Lithium

Question 2

Block reuptake of adrenergic and dopaminergic neurotransmitters

Amitriptyline, imipramine, nortriptyline, despramine, doxepin

Toxicity: excess CNS stimulation - seizures, coma, hypotension, respiratory depression

Answer 2

Tricyclic Antidepressants