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TOXI FINALS > Anti-inflammatory > Flashcards

Anti-inflammatory Flashcards

1
Q

Tissue damage

A

arachidonic acid

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2
Q

lipo-oxygenase pathway

A

leukotrienes

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3
Q

cyclo-oxygenase pathway

A

thromboxanes
prostaglandins

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4
Q

Tissue damage —arachidonic acid
1. lipo-oxygenase pathway
> leukotrienes
2. cyclo-oxygenase pathway
> thromboxanes
> prostaglandins
*** Inflammation

A
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5
Q

Block the cyclo-oxygenase pathway

Anti-inflammatory

Fluid retention, weight gain, osteoporosis, gastrointestinal bleeding and mental changes

A

Corticosteroids

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6
Q

Anti-inflammatory w/o undesirable side effects

Acetaminophen/Paracetamol

Acetylsalicylic acid/Aspirin

Naproxen, Ibuprofen, Piroxicam

A

NSAIDS

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7
Q

Analgesic, antipyretic and anti-inflammatory

Lower doses: anti-thrombotic

Chronic toxicity: tinnitus, muffled hearing

Acute toxicity : acidosis

Reye’s syndrome: hepatotoxicity

A

Aspirin

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8
Q

Analgesic and anti-pyretic

Metabolites : glucoronide and sulfate conjugates

Acute toxicity : nausea, vomiting and abdominal pain

Chronic toxicity : anemia, renal damage, GI disturbances

A

Acetaminophen

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TOXI FINALS (8 decks)

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