Management of GORD and peptic ulcers Flashcards
Alginates
Peptac
Gaviscon (rafting agents)
Antacids
Co-magaldrox
Magnesium Trisilicate
PPIs
Omeprazole (10mg, 20mg, 40mg)
Lansoprazole (15mg, 30mg)
Esomeprazole (20mg, 40mg) Pantoprazole (20mg, 40mg)
Rabeprazole (10mg, 20mg)
PPI dosage forms
Tablets
Capsules
Granules
Dispersible tablets
Oral liquids
Injections
PPI cautions
Risk of bone fracture for prolonged use
Increased C. diff
Mask cancer symtoms
Rebound hyper-secretion of acid
PPI side interactions
Omeprazole & Esomprezaole decrease antiplatelet effect of clopidogrel
Pantoprazole increases anticoagulant effect of warfarins
PPI side effects
Abdominal pain, headaches
Arthralgia, parasthesia
Confusion, gynaecomastia
H2 antagonists
Ranitidine (150mg, 300mg) Cimetidine (200mg, 400mg, 800mg) Famotidine (20mg, 40mg)
Nizatidine (150mg, 300mg)
H2 antagonist dosage forms
Tablets
Capsules
Effeverscent tablets
Oral liquids
Injections
H2 antagonist interactions
Cimetidine increases blood concentration of erythromycin
Famotidine & Ranitidine reduce plasma concentration of atazanavir
H2 antagonist side effects
Diarrhoea, dizziness
Erythema multiform
Hepatitis, confusion
Chelates and complexes
Sucralfate (1000mg)
Tripotassium dicitratobismuthate (120mg)
Prostaglandin analogue
Misoprostol (200mcg)
Pro-kinetic drugs
Domperidone
Metoclopramide