Chemistry of Inflammation drugs Flashcards
1
Q
Aminosalicylates
A
Carboxylic acid converted into sodium salt
Di-sodium salt is more water soluble
2
Q
Aminosalicylates MOA
A
Colon site of action
Sulfalazine - a pro drug
Mesalazine - breakdown to active 5-Aminosalicylic acid (5-ASA) - by gut flora
3
Q
Sulfalazine
A
Sulfapyridine from sulfalazine has side effects
Balsalazide and olsalazine designed
4
Q
Colon absorption
A
Low in oxygen
pH 6-7
Reductive environment
Bacterial azo-reductase cleave sulfalazine azo bond
5
Q
Oral coated tablets
A
Disintegrate at pH 7 in intestine
