Mammalian part 3 Flashcards
Endocytic pathway
Everything that comes the cell in
Secretory pathway
Everything that the cell excretes
Retrieval pathway
Shipping things inside the cell
Endocytosis
‘Eating’ the cargo, different forms because of different sizes of the cargo
Phagocytosis
Endocytosis of a large solid particle
Pinocytosis
Endocytosis of extracellular fluid
Receptor-mediated endocytosis
Endocytosis with a coated vesicle
Phosphoinositide
Marks vesicle so it knows where to go
SNAREs
On recieving membrane to fuse vesicle with membrane
Tethering complex
Pulls vesicle closer to membrane so SNAREs can fuse it
NSF complex
Untangles SNAREs after vesicle is fused with the membrane
Clathrin coat
Responsible for all the vesicles formation traveling inside the cell except ER to Golgi
COP1
Coat for vesicle traveling Golgi –> ER
COP2
Coat for vesicle traveling ER –> Golgi
N-Glycosylation
Posttranslational processing of protein in Golgi, ER–>Golgi
O-glycosylation
In Golgi, sugar by sugar, negative charge
Proteolic cleavage
Post translational processing of golgi in protein
Lysosome
‘garbage bag’ of the cell
Autophagy
Recycling of cytoplasm and organelles by lysosomes
Mannose 6 phosphate
Triggers endosomal targeting and constitutive exocytosis, lysosomal enzymes
RAB cascade
Early endosome –> lysosome
PAMP
pathogen molecule (bacteria, virus) that activate PRRs
DAMP
Host cell molecule that activates PRR
PRR
Patern recognition center
Cytokine
Effector molecule that signales, activates sensors (pro or anti inflammantory)
Complement system
Small molecules produced by liver that recognize infection
Phagocytes
Seek and destroy pathogens, macrophages, dendtrites and neutrophilic
NK cells
Kill when abscence of MHC-1, virus infected cells or tumor cells
MHC-1
Present on cytolytic T-cells, present the antigen
MHC-2
Present on helper T-cell, present the antigen
Effector CD8+ cytolytic T-cell
Kills cell that present antigen on MHC-1 (mostly virusus and cancercells)
Helper CD4+ T-cells
Activates B-Cells
Repertoire scanning
Manu sequential interactions with different T-cells to find cognate T-cells
