Mammalian part 3

Question 1

Endocytic pathway

Answer 1

Everything that comes the cell in

Question 2

Secretory pathway

Answer 2

Everything that the cell excretes

Question 3

Retrieval pathway

Answer 3

Shipping things inside the cell

Question 4

Endocytosis

Answer 4

‘Eating’ the cargo, different forms because of different sizes of the cargo

Question 5

Phagocytosis

Answer 5

Endocytosis of a large solid particle

Question 6

Pinocytosis

Answer 6

Endocytosis of extracellular fluid

Question 7

Receptor-mediated endocytosis

Answer 7

Endocytosis with a coated vesicle

Question 8

Phosphoinositide

Answer 8

Marks vesicle so it knows where to go

Question 9

SNAREs

Answer 9

On recieving membrane to fuse vesicle with membrane

Question 10

Tethering complex

Answer 10

Pulls vesicle closer to membrane so SNAREs can fuse it

Question 11

NSF complex

Answer 11

Untangles SNAREs after vesicle is fused with the membrane

Question 12

Clathrin coat

Answer 12

Responsible for all the vesicles formation traveling inside the cell except ER to Golgi

Question 13

COP1

Answer 13

Coat for vesicle traveling Golgi –> ER

Question 14

COP2

Answer 14

Coat for vesicle traveling ER –> Golgi

Question 15

N-Glycosylation

Answer 15

Posttranslational processing of protein in Golgi, ER–>Golgi

Question 16

O-glycosylation

Answer 16

In Golgi, sugar by sugar, negative charge

Question 17

Proteolic cleavage

Answer 17

Post translational processing of golgi in protein

Question 18

Lysosome

Answer 18

‘garbage bag’ of the cell

Question 19

Autophagy

Answer 19

Recycling of cytoplasm and organelles by lysosomes

Question 20

Mannose 6 phosphate

Answer 20

Triggers endosomal targeting and constitutive exocytosis, lysosomal enzymes

Question 21

RAB cascade

Answer 21

Early endosome –> lysosome

Question 22

PAMP

Answer 22

pathogen molecule (bacteria, virus) that activate PRRs

Question 23

DAMP

Answer 23

Host cell molecule that activates PRR

Question 24

PRR

Answer 24

Patern recognition center

Question 25

Cytokine

Answer 25

Effector molecule that signales, activates sensors (pro or anti inflammantory)

Question 26

Complement system

Answer 26

Small molecules produced by liver that recognize infection

Question 27

Phagocytes

Answer 27

Seek and destroy pathogens, macrophages, dendtrites and neutrophilic

Question 28

NK cells

Answer 28

Kill when abscence of MHC-1, virus infected cells or tumor cells

Question 29

MHC-1

Answer 29

Present on cytolytic T-cells, present the antigen

Question 30

MHC-2

Answer 30

Present on helper T-cell, present the antigen

Question 31

Effector CD8+ cytolytic T-cell

Answer 31

Kills cell that present antigen on MHC-1 (mostly virusus and cancercells)

Question 32

Helper CD4+ T-cells

Answer 32

Activates B-Cells

Question 33

Repertoire scanning

Answer 33

Manu sequential interactions with different T-cells to find cognate T-cells