Malignant Tumors of the Liver

Question 1

What condition has a strong association with hepatocellular carcinoma?

Answer 1

HBV

Question 2

What component of HBV promotes tumorgenesis of HCC?

Answer 2

X gene encoding the protein HBxAg that inactivates tumor suppressor genes

Question 3

What are RFs for the genesis of HCC?

Answer 3

• Hemochromatosis
• HBV
• HCV
• Alpha1 AT deficiency
• Alcohol
• Aflatoxin B1

NOT cirrhosis

Question 4

Typical presentation of HCC?

Answer 4

Painful and enlarging mass

Question 5

What marker levels are typically elevated in HCC?

Answer 5

Alphafetoprotein

Question 6

From where does cholangiocarcinoma arise?

Answer 6

Biliary epithelium

Question 7

Where in the biliary tree does cholangiocarcinoma arise?

Answer 7

Anywhere in the biliary tree

Question 8

What endemic critter causes cholangiocarcinoma?

Answer 8

C. sinensis

Question 9

Rare malignant tumor of childhood containing embryonal and fetal cells?

Answer 9

Hepatoblastoma

Question 10

Clinical Syx of hepatoblastoma?

Answer 10

Serum alpha-fetoprotein elevation, abdominal enlargement, vomiting and failure to thrive

Question 11

Only significant sarcoma of the liver?

Answer 11

Hemangiosarcoma

Question 12

Cause of hemangiosarcoma?

Answer 12

Thorium dioxide, arsenic, vinyl chloride

Question 13

Most common malignant tumor of the liver?

Answer 13

Metastatic cancer

Question 14

Most common Syx of metastatic cancer?

Answer 14

Weight loss