Cholestatic Syndromes of Infancy

Question 1

What is the characteristic uscopic lesion of neonatal hepatitis?

Answer 1

Giant cell transformation of hepatocytes (giant cell transformation)

Question 2

Lack of a lumen in the biliary tree?

Answer 2

Biliary atresia

Question 3

What is extrahepatic biliary atresia?

Answer 3

Cholestatic disease with inflammatory obliteration of the lumen of all or part of the biliary tree outside the liver, not associated with calculi, tumor, or rupture

Question 4

What is intrahepatic biliary atresia?

Answer 4

Few bile ducts w/i the liver

Question 5

Intraheptaic biliary atresia syndrome associated with Notch signaling pathway?

Answer 5

Algaille sndrome