Drug Induced Liver Injury Flashcards
Most common cause of acute liver failure in the US?
Drugs
What are the defining characteristics of a predictable drug-induced hepatotoxicity?
- Agent in sufficiently high doses always produces liver cell damage
- Extend of hepatic injury is dose dependent
- Same lesions are seen in different animal species
- Liver necrosis is characteristically zonal, generally centrilobular
- Time b/w exposure and liver necrosis is short
What process do most drug reactions follow?
Most drug rxns are unpredictable and seem to represent idiosyncratic events
What is the typical pathology observed in drug reactions?
Drugs can cause nearly the entire range of pathologies seen in non-drug induced liver disease
What is the most common cause of acute liver failure in the US?
Acetaminophen-induced hepatotoxicity
In what tpe of drug rxns are inflammatory reactions common?
Unpredictable hepatotoxic drug rxns
Two morphologic patterns encountered with drug induced fatty liver?
- Macrovesicular Steatosis
- Microvesicular Steatosis
Condition in which hepatocytes and Kupffer cells are enlarged with foamy cytoplasm?
Macrovesicular steatosis
Difference b/w macrovesicular and microvesicular steatosis in terms of Px?
Uvesicular fatty liver is commonly associated w/ severe, sometimes fatal liver disease
Disease of children characterized by microvesicular steatosis, hepatic failure, and encephalopathy
Reye syndrome
Occlusion of the hepatic veins?
Budd-Chiari Syndrome
Peculiar hepatic lesion, characterized by cystic, blood-filled cavities not lined by endothelial cells
Peliosis hepatis typically following the use of anabolic sex steroids
Dye used that when administered causes altered hepatic morphology?
Thorium dioxide
