Malignancy Flashcards
What additional thing do SCLC have?
Neurosecretory granules so cause multiple paraneoplastic conditions
What kinds of non small cell LC are tehre?
Squamous cell (35%) Adenocarcinoma (25%)
What are signs and symptoms of lung cancer?
Shortness of breath Cough Haemoptysis (coughing up blood) Finger clubbing Recurrent pneumonia Weight loss Lymphadenopathy – often supraclavicular nodes are the first to be found on examination
What are CXR signs of cancer?
Hilar enlargement
“Peripheral opacity” – a visible lesion in the lung field
Pleural effusion – usually unilateral in cancer
Collapse
What are surgical procedures done in NSCLC?
Segmentectomy, lobectomy or wedge resection
WHat is done to manage SCLC?
Chemo and radio
Which has worse prognosis? SCLC or NSCLC?
SCLC
What are some extrapulmonary manifestations of lung cancer?
Recurrent laryngeal nerve palsy Phrenic nerve palsy SVCO (Pemberton's sign) Horner's syndrome SiADH Cushings (SCLC)
What is Lambert Eaton Myasthenic Syndrome?
antibodies produced against SCLC cells that leads of proximal muscle weakness and intraocular muscles (diplopia), ptosis, slurred speech and dysphasia. Weakness gets worse the longer muscles are used.
Looks like MG
Which cells are affected in mesothelioma?
Mesothelial cells
Which causes more mets? Small cell or non
SCLC
What staging used for lung cancer?
TNM
Where do lung mets go?
Lymph, bone, brain, liver and adrenals
Where to mets to lungs come from?
Breast, colorectal, prostate, melanoma, thyroid, lymphoma
