Maligant GYN Path & Interventions

Question 1

Ovarian cancer is the _____ leading cause of cancer death.

Answer 1

8th

Question 2

What stage is ovarian cancer most often diagnosed at?

Answer 2

60-70% of the time stage 3

Question 3

What is the 5 year survival rate of ovarian cancer? 5 year survival rate at stage 1?

Answer 3

30-50%, 80% at stage 1

Question 4

What are risk factors for ovarian cancer?

Answer 4

• avg age 50
• hx of unsuccessful pregnancies/nulliparity
• early menses/late meno
• fam hx ovarian ca, BRCA 1/2 gene mutation

Question 5

What is CA 125?

Answer 5

biological tumor marker that is elevated w/ presence of ovarian cancer or other gyn ca

Question 6

What percentage of cases involve elevated CA 125?

Answer 6

80%

Question 7

What percentage of stage 1 disease is CA 125 detected in?

Answer 7

less than 50%

Question 8

What kind of tumors is CA 125 insensitive to?

Answer 8

mucinous and germ tumors

Question 9

What is the MC gyn malignancy?

Answer 9

endometrial cancer

Question 10

What causes endometrial carcinoma?

Answer 10

excessive estrogen/stimulation

Question 11

Who is endometrial carcinoma common in?

Answer 11

meno/postmeno, white

Question 12

What are risk factors for endometrial ca?

Answer 12

• obesity, anovulation premeno
• HRT
• atypical hyperplasia
• tamoxifen