Males Health

Question 1

What is the prostate?

Answer 1

Male reproductive gland

Question 2

What is the prostate made up of?

Answer 2

Epithelial cells

Question 3

What 3 conditions are associated with the Prostate?

Answer 3

• prostatitis
• benign prostate hyperplasia
• prostate cancer

Question 4

What happens in BPH?

Answer 4

An increase in epithelial and stromal cells

These are closest to urethra - causes construction and urgency

There is a increase in DHT

Question 5

Is BPH cancerous

Answer 5

NO

the gland is enlarged but NOT cancerous

Question 6

Risk factors of BPH?

Answer 6

increase in age (>45) & DHT

Question 7

Common symptoms of BPH?

Answer 7

• difficulty in starting to urinate
• increased frequency to urinate
• difficulty in fully emptying bladder

Question 8

What issues can arise from not completely empty bladder?

Answer 8

Urine accumulation =
• bacterial infection + cystitis

Question 9

How is urinary retention relieved?

Answer 9

Catheterisation

Question 10

Non-pharmacological treatment?

Answer 10

Lifestyle advice:
• reduce fluid intake
• advoid excessive drinking at night
• empty bladder before night and long trips
• train bladder

Question 11

Which pharmacology treatment are used in BHP?

Answer 11

• alpha blockers
• 5a- Reductase

Question 12

Examples of Alpha Blockers?

Answer 12

• tamsulosin
• prazosin
• Alfuzosin

SIN

Question 13

Alpha Blockers MOA

Answer 13

Selectively blocks alpha receptors in the NS

Relaxes the prostate neck & smooth muscle

Question 14

What side effect are associated with Alpha blockers?

Answer 14

• headache
• dizziness
• drowsiness
• ejaculation issues

Question 15

Examples of 5a- reductase inhibitors

Answer 15

Fintasterdine
Dutasteride

Question 16

What is the mode of action of 5a -reductase inhibitors

Answer 16

Inhibits 5a reductase - conversion of testosterone to dihydrotestosterone

Reducing the size of prostate - decreasing resistance to flow

Question 17

Side affects associated with 5a-reductase inhibitors?

Answer 17

Sextual dysfunction & reduced ejaculation volume

Pregnant women should not handle broken tables

Question 18

What should be monitored when taking 5a-reductase inhibitors?

Answer 18

PSA

Question 19

If prostate size is > 30-40cm which drug should be used

Answer 19

5a-reductase inhibitors

Question 20

Can Alpha blockers & 5a-reductase inhibitors be combined

Answer 20

Yes

Question 21

Supplying OTC Tamsulosin

Answer 21

Supply criteria:
• male > 45
• symptoms of BPH for 3 months
• 2 weeks supply initially

Counselling
• 400mcrg OD
• swallow whole
• take after first meal