Male Reproductive Physiology - Montemayor Flashcards

1
Q

35yo M unable to conceive after 3 years

sparse facial hair
decreased axillary and pubic hair growth

testes small and firm
low testicular volume

high LH and FSH
low Testosterone
low sperm

karyotype XXY

A

klinefelters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

klinefelters

A

XXY

seminiferous tubule dysgenesis

most common form male hypogonadism**

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

intrauterine development of testes

A

SRY - on Y chromosome

transcription factor - TDF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

AMH

A

antimullerian hormone
-for mullerian duct regression

from sertoli cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

sertoli cells

A

produce AMH

cause regression of female sex tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

seminal vesicles, ejaculatory duct, vas deferens development

A

testosterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

testosterone production

A

leydig cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

before LH effect

A

hCG promotes fetal leydig to form testosterone**

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

hCG

A

can be used to stimulate spermatogenesis

similar to LH effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

penis, scrotum, prostate development

A

DHT
-dihydrotestosterone

binds greater affinity to testosterone angrogen receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

testosterone > DHT conversion

A

5 alpha reductase 2

can be deficient - ambiguous external genitalia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

retention of wolffian ducts

A

testosterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

gynecomastia

A

elevated estradiol

-increased E:T ratio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

androgen to estrogen conversion

A

CYP-19 aromatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

hormone initiate puberty

A

pulsatile GnRH**

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

primary hypogonadism

A

elevated gonadotropin

androgen decreased levels

17
Q

androgen actions

A

variety of androgenic and anabolic effects

18
Q

internal genitalia

A

testosterone

19
Q

external genitalia

A

DHT

20
Q

circulating testosterone

A

majority is bound

SHBG - 45-60%
serum albumin 40%

21
Q

protein testosterone concentration in testes

A

androgen binding protein - ABP

22
Q

high T in testes

A

100x circulating

of promotion of adequate spermatogenesis

23
Q

promote LH and FSH secretion

A

GnRH pulsatile

24
Q

target of LH in testes

A

leydig cells

25
Q

target of FSH in testes

A

sertoli cells

26
Q

continuous GnRH

A

will inhibit gonadotropin secretion

for prostate cancer

27
Q

sertoli functions

A
produce aromatase
blood testis barrier
hormone receptors
produce ABP
produce AMH
produce inhibin B - neg feedback on FSH
28
Q

T, DHT, and E

A

negative feedback on LH

29
Q

3 hormones for spermatogenesis

A

testosterone - high testicular concentration (ABP bound)
FSH and LH

also estradiol and GH

30
Q

tx for patient with klinefelter

A

androgen replacement therapy

exogenous T - virilzation of secondary male sexual traits

fertility - testes fibrotic - no work in this klinefelters

31
Q

exogenous testosterone for fertility

A

no - just has negative feedback on entire axis

need ABP - to keep high concentration in testes but low circulating

32
Q

eunuchoidism

A

absense of secondary sex characteristics

gonadal failure before puberty

33
Q

13yo M b/l testicles absence

testes in inguinal canal

failure to descend causes defect of?

A

maturation of spermatogonia

34
Q

25yo M not able to conceive

decreased facial and axillary hair
decreased penile length
hypogonadism

due to?

A

DHT

35
Q

DHT

A

external genitalia and secondary sex characteristics

36
Q

continuous long lasting of what to delay puberty

A

GnRH agonist

37
Q

FSH Abs for male contraception

men expected to have?

A

decreased serum inhibin B

remove FSH on sertoli cell function**

38
Q

22yo M seminiferous tubule dysgenesis

sertoli cells do what

A

maintain blood testis barrier

39
Q

leydig cell vs. sertoli cell function

A

study it