Male Reproductive Physiology - Montemayor Flashcards
35yo M unable to conceive after 3 years
sparse facial hair
decreased axillary and pubic hair growth
testes small and firm
low testicular volume
high LH and FSH
low Testosterone
low sperm
karyotype XXY
klinefelters
klinefelters
XXY
seminiferous tubule dysgenesis
most common form male hypogonadism**
intrauterine development of testes
SRY - on Y chromosome
transcription factor - TDF
AMH
antimullerian hormone
-for mullerian duct regression
from sertoli cells
sertoli cells
produce AMH
cause regression of female sex tract
seminal vesicles, ejaculatory duct, vas deferens development
testosterone
testosterone production
leydig cells
before LH effect
hCG promotes fetal leydig to form testosterone**
hCG
can be used to stimulate spermatogenesis
similar to LH effects
penis, scrotum, prostate development
DHT
-dihydrotestosterone
binds greater affinity to testosterone angrogen receptor
testosterone > DHT conversion
5 alpha reductase 2
can be deficient - ambiguous external genitalia
retention of wolffian ducts
testosterone
gynecomastia
elevated estradiol
-increased E:T ratio
androgen to estrogen conversion
CYP-19 aromatase
hormone initiate puberty
pulsatile GnRH**