Dunn OB/GYN XI Flashcards

1
Q

50yo F LMP 3 weeks ago

  • bleeding everyday since last period - 1 pad/day
  • irregular periods last year
  • hot flashes, fatigue, cranky
  • 20 pack years smoker
A

labs - CBC, TSH, FSH, preg test, pap, endometrial bx

menopausal**

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2
Q

tx of menopause

A

HRT

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3
Q

perimenopause

A

time leading up to menopause

ovarian function and hormone production declining but not stopped

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4
Q

menopause

A

permanent cessation of menstrual cycle

not having period 12 months

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5
Q

post menopause

A

time in womens life after last period

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6
Q

premature menopause

A

before age 40

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7
Q

median age perimenopause

A

47

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8
Q

average age reach menopause

A

51

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9
Q

menopause changes

A
vasomotor sx
sleep quality
mood change
urogenital symptoms
sexual disinterest
skin changes
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10
Q

hot flashes

A

may continue years after menopause

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11
Q

with decreased estrogen at menopause

A

bone loss/osteoporosis - HRT tx (estrogen)

more CV disease

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12
Q

decreased progesterone

A

irregular periods

PMS

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13
Q

decreased androgens at menopause

A
mood
energy
libido
muscle weak
osteopenia
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14
Q

HRT

A

does not increase cardiovascular disease if started within 5 years of menopause

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15
Q

risks of HRT

A

VTE -very low

greatest risk of venous thrombolic events - 1st year of use of HRTs

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16
Q

associated with menopause

A

coronary heart disease
osteoporosis

breast ca, colon ca, dementia

17
Q

coronary artery disease

A

HRT reduced risk of death

18
Q

age of initiation of HRT

A

important in determining cardiovascular risk

19
Q

dementia

A

estrogen taken early in menopause is protective**

20
Q

breast cancer

A

HRT no different risk - E/P

21
Q

estrogen only hormone therapy

A

different risk for breast ca

protect against breast ca

unopposed estrogen

22
Q

route of admin

A

transdermal vs. oral

less VTE - patch use

no CV disease risk difference with two routes of admin

23
Q

mild vasomotor symptoms

A

lifestyle changs
isoflavones
black cohosh
vit E

24
Q

moderate to severe vasomotor symptoms

A

HRT - gold standard**
SSRIs and gabapentin
progesterone
clonidine

25
Q

no estrogen

A

osteoporosis

26
Q

24yo F G0 LMP 3 months ago

  • CC irregular periods
  • denies pain with menses
  • very heavy period
  • obese
  • fam hx DM II
  • acne and virilization
  • acanthosis nigricans
A

amenorrhea with irregular menses

hCG - pregnancy test first
TSH, LH, FSH, PRL
US
androgen levels

string of pearls on US and high testosterone levels

27
Q

acne and virilization with acanthosis nigricans

A

high androgens

28
Q

string of pearls

A

PCOS

US finding

29
Q

diagnosis of PCOS

A

rotterdam criteria - need 2 of 3

oligoovulation/anovulation
excess androgen activity
polycystic ovaries on US

30
Q

PCOS

A

don’t need an US

-can diagnose clinically

31
Q

PCOS pathology

A

high levels of testosterone
and estrogen

don’t ovulate - so make estrogen - lots of estrone - increase LH production (positive feedback)

FSH not depressed - follicular growth stimulated

follicules last several month

feedback - LH high and FSH low - no surge

32
Q

causes of PCOS

A

dont know

maybe insulin
maybe inflammation
maybe genetics
maybe fetal androgen exposure

33
Q

complications of PCOS

A
abnormal bleeding
infertility
risk endometrial cancer
incrased CRP
metabolic syndrome
DM II, HTN, HLD,
34
Q

tx of PCOS

A

patient - contraception - give contraception

patient - bleeding - progesterone daily to cause endometrial shedding

patient - hirsutism - oral contraceptive suppress ovarian and adrenal production