Drugs for Male GU Disorders - Martin Flashcards
glyburide
sulfonylurea
-increase insulin release from beta cells of pancreas
metformin
biguanide
-increase insulin sensitivity
most common cause of ED
atherosclerosis
alterations in sexual response
SSRIs
antipsychotics - phenothiazines
alcohol
tx of ED
phosphodiesterase inhibitors
PG E1 analog
PG E1 analog
alprostadil
relaxes trabecular smooth m and dilation of cavernosal arteries
- tx for ED
- injected along penis
PDE5 inhibitors
tx for ED
increased cGMP - more smooth m relaxation of corpora cavernosa
sildenafil
PDE5 inhibitor
viagra
tadalafil
PDE5 inhibitor
cialis
avanafil
PDE5 inhibitor
vardenafil
PED5 inhibitor
levitra
CI for PDE5 inhibitors
nitrates use - myocardial ischemia risk**
daily use PDE5 inhibitor
tadalafil
duration of action 36 hours
30 minute ED drugs
tadalafil
avanafil
1 hour ED drugs
sildenafil
vardenafil
adverse of alprostadil
penile pain
tx male pattern baldness
finasteride
5 alpha reductase inhibitor
tx of BPH
5 alpha reductase inhibitors
alpha1-adrenergic antagonist
prazosin
short acting alpha1 antagonist
-tx for BPH
long acting alpha1 antagonists
terazosin
doxazosin
alfuzosin
tamsulosin
finasteride
5a reducatase inhibitor
dutasteride
5a reductase inhibitor
smooth m in prostate
alpha1A receptor primarily
adverse prazosin
orthostatic HTN and palpitations
abnomal ejaculation
with alfuzosin
saw palmetto
tx of BPH
inhibit 5a reductase and inhibit DHT binding to androgen receptors
tx urinary incontinence
atropine
antagonist at muscarinic ACh receptor
oxybutynin
M3 selective mAChR
used in disorders of GU tract
-reduce urinary frequency
