Male Reproductive Physiology Flashcards

1
Q

Why is the scrotum out-with the abdominal/pelvic cavity?

A

To allow for it to be 1-2 degrees colder to facilitate sperm production

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2
Q

What is the fibrous capsule that surrounds the testes?

A

Tunica albuginea

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3
Q

What are the three cell types within the seminiferous tubules?

A
  • Germ cells
  • Sertoli/sustentacular cells
  • Interstitial/Leydig cells
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4
Q

What is the function of Germ cells in the seminiferous tubules?

A

Produce sperm

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5
Q

What is the function of the sustentacular cells in the seminiferous tubules?

A

Support sperm production, produce inhibin

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6
Q

What is the function of the interstitial cells

A

Produce testosterone

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7
Q

What are the two main functions of the testes?

A
  • Sperm production

- Testosterone production

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8
Q

How long is the average sperm cycle?

A

64 days (about 3 months)

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9
Q

What are the male reproductive hormones?

A
  • GnRH (from hypothalamus)
  • Gonadotrophin’s (LH + FSH from AP)
  • Testosterone (from testicles)
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10
Q

Where does FSH act and what is the effect?

A

Testes and sustentacular cells facilitate spermatogenesis

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11
Q

Where does LH act and what is its effect?

A

Testes and encourages interstitial cells to produce testosterone

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12
Q

What is the positive feedback effect of the interstitial cells producing testosterone?

A

On the sustentacular cells facilitating spermatogenesis

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13
Q

Where does testosterone show negative feedback?

A

on AP and hypothalamus

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14
Q

Where does inhibin show negative feedback?

A

on AP

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15
Q

What is spermatogenesis?

A

Production of sperm from primordial germ cells

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16
Q

What are the two distinct phases of development during spermatogenesis?

A
  • Spermatocytogenesis

- Spermieiogenesis

17
Q

When does spermatogenesis begin and end?

A

Starts and puberty and continues life long (doesn’t end)

18
Q

How does mitotic devision work during spermatogenesis?

A
  1. One mitotic devision (46 chromosomes)
  2. First meiotic division (two cells with haploid chromosome number (23))
  3. Second meiotic division (spermatid - two cells with haploid chromosomes)
  4. Spermatogenesis (maturation of spermatids into functional sperm cells)
19
Q

What factors affect spermatogenesis?

A
  • Medical
  • Lifestyle
  • Combination
20
Q

How can the medical factors that affect spermatogenesis be categorised?

A
  • Pretesticular (problem with hormonal control)

- Testicular (problem at site of production)

21
Q

How can lifestyle factors which affect sperm production be categorised?

A
  • From mother (irreversible bc happens in utero)

- From male (reversible bc most are environmental causes)

22
Q

What steps can be taken to reduce impact of factors affecting fertility?

A
  • Improve lifestyle
  • Optimise underlying medical condition
  • Stop medications or switch to alternative pregnancy compatible medications
  • Reduce STI risk and treat promptly if diagnosed
  • Fertility preservation (sperm freezing prior to surgery/radiotherapy/chemotherapy)