Male Reproductive Flashcards
2 functions of the testis
spermatogenesis and Secretion of Testosterone
80% of testicular mass is composed of ________ where _________ takes place
seminiferous tubules, spermatogenesis
connective tissues contains te _______ cells where __________ is secreted
Leydig cells, testosterone
seminiferous tubules contain______ cells which respond to ____
Sertoli cells which respond to FSH
Leydig cells contain ____ receptors and _____ results in _____ release
LH receptors and situation results in testosterone release
GnRH is released as a ______
causing ____ and ___ to be released by _____ and ____ in the anterior pituitary
secretory burst from the hypothalamus, causing FSH and LH secreting cells to secrete FSH and LH. FH is used for spermatid remodeling and Sertoli cell functioning, while LH stimulates Leydig cells to produce testosterone
testosterone regulation
controls LH more than FSH which is essential for mitosis and meiosis
Making testosterone
LH receptors on leading cells stimulate testosterone
(FSH receptors on sertolie cells are able to initiate sperm maturation in testosterone)
testosterone is then free in blood or bound to bound to hormone binding globulin
this testosterone can then be converted to DHT in peripheral tissue
how does testosterone synthesis begin
with the conversion of cholesterol when LH binds to a receptor
testosterone and the seroli cell
testosterone diffuses into the seroli cell and stimulate the synthesize of ABH
also stimulates the synthesis of growth facts that will support the developing sperm
ABH
synthesized by settle cells and secreted into the lumen of seminiferous tubules, the seminiferous tubules contain a high local testosterone concentration which is 50 times higher than that of the blood
FSH and sertoli cell
FSH will bind to a receptor on the Seroli cell via the activation of protein kinase A
this will produce the secretion of inhibins, activate the aromatase enzyme, and the make the seroli cell produce androgen binding protein
ABP is secreted into
the lumen of seminiferous tubules
cholesterol to testosterone
LH acts on cholesterol, 17 Beta HSD enzyme is present in the testes causing testosterone to be produced in the testes,
DHT is produced outside of the testes once testosterone is released in the blood
what converts testosterone to DHT
5 alpha reductase
DHT targets
external ggenitalia, male pattern body hair, temporal baldness, and prostate
testosterone targets
wolffian duct, brain, muscle, body hair,spermatogenesis and libido
type 1 5 alpha reductase found in
liver and non genital skin
type 2 5 alpha reductase found in
genital tissue
DHT is ___ as ____ as testosterone
twice as potent as testosterone
where are e2 receptors
male reproductive tract, prostate and bone