Male Reproductive Flashcards

1
Q

2 functions of the testis

A

spermatogenesis and Secretion of Testosterone

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2
Q

80% of testicular mass is composed of ________ where _________ takes place

A

seminiferous tubules, spermatogenesis

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3
Q

connective tissues contains te _______ cells where __________ is secreted

A

Leydig cells, testosterone

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4
Q

seminiferous tubules contain______ cells which respond to ____

A

Sertoli cells which respond to FSH

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5
Q

Leydig cells contain ____ receptors and _____ results in _____ release

A

LH receptors and situation results in testosterone release

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6
Q

GnRH is released as a ______

causing ____ and ___ to be released by _____ and ____ in the anterior pituitary

A

secretory burst from the hypothalamus, causing FSH and LH secreting cells to secrete FSH and LH. FH is used for spermatid remodeling and Sertoli cell functioning, while LH stimulates Leydig cells to produce testosterone

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7
Q

testosterone regulation

A

controls LH more than FSH which is essential for mitosis and meiosis

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8
Q

Making testosterone

A

LH receptors on leading cells stimulate testosterone
(FSH receptors on sertolie cells are able to initiate sperm maturation in testosterone)
testosterone is then free in blood or bound to bound to hormone binding globulin
this testosterone can then be converted to DHT in peripheral tissue

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9
Q

how does testosterone synthesis begin

A

with the conversion of cholesterol when LH binds to a receptor

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10
Q

testosterone and the seroli cell

A

testosterone diffuses into the seroli cell and stimulate the synthesize of ABH
also stimulates the synthesis of growth facts that will support the developing sperm

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11
Q

ABH

A

synthesized by settle cells and secreted into the lumen of seminiferous tubules, the seminiferous tubules contain a high local testosterone concentration which is 50 times higher than that of the blood

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12
Q

FSH and sertoli cell

A

FSH will bind to a receptor on the Seroli cell via the activation of protein kinase A
this will produce the secretion of inhibins, activate the aromatase enzyme, and the make the seroli cell produce androgen binding protein

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13
Q

ABP is secreted into

A

the lumen of seminiferous tubules

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14
Q

cholesterol to testosterone

A

LH acts on cholesterol, 17 Beta HSD enzyme is present in the testes causing testosterone to be produced in the testes,
DHT is produced outside of the testes once testosterone is released in the blood

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15
Q

what converts testosterone to DHT

A

5 alpha reductase

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16
Q

DHT targets

A

external ggenitalia, male pattern body hair, temporal baldness, and prostate

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17
Q

testosterone targets

A

wolffian duct, brain, muscle, body hair,spermatogenesis and libido

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18
Q

type 1 5 alpha reductase found in

A

liver and non genital skin

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19
Q

type 2 5 alpha reductase found in

A

genital tissue

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20
Q

DHT is ___ as ____ as testosterone

A

twice as potent as testosterone

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21
Q

where are e2 receptors

A

male reproductive tract, prostate and bone

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22
Q

primary hypogonadism

A

sex steroids down, LH and FSH up

problem in the testes

23
Q

pituitary hypogonadism

A

sex steroids down, Lh down, ash down

problem in the pituitary

24
Q

anabolic steroid use

A

sex steroids up, LH down, FSH usually down

25
Q

exogenous testosterone

A

inhibits LH and causes leading cell atrophy and reduced testicular testosterone production. this suppresses spermatogenesis

26
Q

fetal testicular function

A

testosterone production commences in week 7 of gestation raises to 300-400 ng/DL then falls, male phenotype will develop

27
Q

neonatal testicular function

A

surge in testosterone due to rise in plasma LH then will fall to low level by age 1, male gender should be imprinted

28
Q

puberty

A

surge in testosterone

sexual maturation occurs

29
Q

senescence

A

testosterone levels decline at rate of 1.2% per year being at 50

30
Q

ampulla

A

provides additional storage site for sperm,

secretes fluid rich in citrate and fructose in order to nourish the ejactuated sperm

31
Q

semen is made up of

A

secretions from the accessory sex glands, the seminal vesicles, prostate and bulbourethral gland

32
Q

temp and spermatogenesis

A

Spermatogenesis depends on lower scrotal temperatures.

33
Q

seminal vesicles

A

empty into emulators duct and secrete fluids

34
Q

fluids from seminal vesicles

A

fructose energy source for semen
prostaglandins to stimulate contractions
fibrinogen is precursor of fibrin with will form a clot

35
Q

what percent of fluid is from the seminal vesicles

A

about 65 to 75 of the Toal ejactulated volume

36
Q

prostate

A

surrounds ejaculatory duct and urethra

secretes milky alkaline fluid

37
Q

what is the importance of the prostates alkaline milky fluid

A

neutralizes the acidic vaginal secretions

38
Q

prostate fluid volume of semen

A

25 to 30 % of the semen volume

39
Q

what is the importance of the prostate’s zinc component

A

stabilizes the DNA containing chromatin in the sperm cells

40
Q

what is the importance of the prostates clotting enzyme

A

produce fibrin from fibrinogen and clots the sperm

41
Q

what is the importance of the prostate’s fibrinolysin component

A

breaks down clot following withdraw

42
Q

bulbourethral gland

A

secretes a mucus like fluid prior to ejaculation
for lubrication and neutralize traces of urine
contributes to the jelly like texture of semen
one percent of semen

43
Q

how does excitation occur

A

it is initiated by stimuli, sexual arousal, and causes a spinal reflex resulting in an erection

44
Q

plateau phase

A

intensification of excitation responses, ANS activity happens throughout resulting in emission

45
Q

orgasmic phase

A

education occurs due to muscular contractions resulting in pleasure

46
Q

resolution phase

A

genital and body systems return to pre arousal state

47
Q

flaccid penis

A

arteries have relatively high degree of a vascular tone

48
Q

erection

A

CNS imitation, neural activation, NO release, vasodilation of penile vessels, relaxation of corporal SM, occupation of subtunical veins
this mains full rigidity of the penis

49
Q

erection reflex

A

basic spin reflex
mechanoreceptors stimulated in glans penis
takes about 5 to 10 seconds to happen but can be inhibited or stimulated by higher brain centers

50
Q

erection is causes by

A

dilation of blood vessels in the erectile tissue of the penis, which is a parasympathetic response

51
Q

emission

A

Emission is movement of semen from the epididymis, vas deferens, seminal vesicles, and prostate to the ejaculatory ducts.

52
Q

emission movement is mediated by

A

sympathetic nervous system

53
Q

internal sphincter of the bladder

A

Simultaneously, there is sympathetic-mediated contraction of the internal sphincter of the bladder, which prevents retrograde ejaculation of semen in to the bladder.

54
Q

emission and ejaculation

A

Emission precedes ejaculation, but can continue during ejaculation.