Male Reproduction Flashcards
What are the male and female target cells for FSH?
Sertoli cells, granulosal cells
What are the male and female target cells for LH?
Leydig cells, thecal cells
During the reproductive years, LH is produced in abundance over FSH.
T/F
True
What is the function of Sertoli cells?
•Sertoli cells provides the cellular environment for development of sperm - nurtures their development
What is the function of Leydig cells?
•Leydig cells are interstitial cells surrounding the seminiferous tubules that secrete testosterone
Where does spermatic mitosis take place?
basal compartment
Where does spermatic meiosis take place?
central compartment
The genetic endowment of the secondary spermatocyte is:
A. 46 chromosomes per cell, 2 chromatids per chromosome
B. 23 chromosomes per cell, 2 chromatids per chromosome
C. 23 chromosomes per cell, 1 chromatid per chromosome
B. 23 chromosomes per cell, 2 chromatids per chromosome
Mitosis takes place on the luminal side of the blood-testes barrier (inside the barrier).
T/F
False. Meiotic takes place inside the barrier, though.
Which cell type is not protected by the blood-testes barrier?
A. Spermatogonia
B. Primary spermatocytes
C. Secondary spermatocytes
D. Spermatids
A. Spermatogonia
How are abnormal sperm dealt with?
Sertoli cells autodigest sperm that do not meet quality control.
Movement of sperm is both passive and enhanced by smooth muscle contractions.
A. True
B. False
True
~Pressure created by continuous secretion of fluid from Sertoli cells move non-motile sperm
~Also moved by peristaltic contractions of smooth muscle associated with epididymis and vas deferens
Pharmacotherapy for erectile dysfunction would focus on:
A. Sympathetic innervation
B. Parasympathetic innervation
B. parasympathetic
Which ANS is dominant during ejaculation?
sympathetic - neural norepinephrine
Which ANS is dominant during penile erection?
parasympathetic
Growth of the prostrate gland and male baldness depends on dihydrotestosterone rather than testosterone.
A. True
B. False
True
GnRH release is greater at night and lower during the day.
T/F
False.
~A pulse of GnRH is secreted approximately every 90 minutes triggering LH and FSH release from the anterior pituitary.
~Pulses of FSH act on Sertoli cells to stimulate paracrine agents that stimulate spermatogenesis.
What is the action of inhibin?
Inhibits FSH secretion from the anterior pituitary
What is the inhibitory action of testosterone?
- inhibits LH secretion from the anterior pituitary
- inhibits GnRH secretion from the hypothalamus
Who releases ABP (androgen-binding protein) and why?
- Sertoli cells secrete fluid containing androgen-binding protein (ABP)
- Testosterone binds to ABP and crosses blood-testes barrier
98% of circulating testosterone is bound to plasma proteins including androgen-binding protein.
A. True
B. False
A. True
Androgens stimulate the synthesis of sex steroid-binding globulins (androgen-binding protein).
A. True
B. False
False. Synthesis is stimulated by estrogens and inhibited by androgens.
Estrogen has the ability to pass through membranes but there are cells that have estrogen receptors.
T/F
True.
E.g., in the brain
Who releases inhibin?
Sertoli cells
Secondary hypogonadism
- How would the hormone levels throughout axis change if there was hyposecretion at the level of the pituitary?
- Level of LH and FSH?
- Level of testosterone?
LH & FSH: low
testosterone: low
Klinefelter syndrome
- Level of LH and FSH?
- Level of testosterone?
LH & FSH: high
testosterone: low
