Malaria

Question 1

most common benign type of malaria ?

Answer 1

plasmodium vivax

Question 2

protective factors for malaria ?

Answer 2

GCPD deficiency
sickle cell disease
HLA-B53
absence of Duffy antigens

Question 3

features of severe malaria ?

Answer 3

schizonts on blood film 
parasite count > 2%
temperature > 39 degrees
acidosis
severe anaemia
complications
hypoglycaemia

Question 4

complications of malaria ?

Answer 4

pulmonary oedema, ARDS
DIC
jaundice 
cerebral malaria: confusion, headache 
acute renal failure: black water fever, secondary to intravascular haemolysis 
algid malaria

Question 5

prophylaxis of malaria in pregnant women ?

Answer 5

chloroquine

if giving proguanil then give folate supplement 5mg OD

Question 6

prophylaxis of malaria in children ?

Answer 6

diethyltoluamide (DEET)

Question 7

side effects of doxyclycline ?

Answer 7

photosensitivity

oesophagitis

Question 8

1st line treatment in management of severe malaria ?

Answer 8

IV artesunate

Question 9

1st line treatment in uncomplicated malaria ?

Answer 9

artemisinin-based combination therapy (ACT)

• artesunate + mefloquine etc
• chloroquine (non-falciparum malaria)

Question 10

contraindication to chloroquine use ?

Answer 10

epilepsy

children

Question 11

contraindication to doxycycline use ?

Answer 11

pregnancy

children < 12 yrs

Question 12

investigations for diagnosis of malaria ?

Answer 12

thick and thin blood film
quantitive buffy coat
rapid antigen test i.e. parasight F

Question 13

side effects of mefloquine ?

Answer 13

neuropsychiatric disturbance

contraindicated in epilepsy
dizziness

Question 14

side effect of chloroquine ?

Answer 14

headache