Malaria Flashcards
What are the quinine derivatives?
They all end in quinine duh Quinine Chloroquine Hydroxychloroquine Mefloquine Primaquine
How the all quinine work?(exception primaquine)
They accumulate in parasite’s food vacuole
They disrupt heme polymerization to hemozoin –> cause oxidative damage to membrane & digestive proteases
How does primaquine work?
Forms quinolone-quinone intermediates that oxidize schizont membranes.
What do all quinines treat?
Prophylaxis, treatment of acute malarial attacks
Cool fact about quinine?
Also called quinidine(used in anti-arrhythmias)
Important side effect of quinine?
Cinchonism - muscarininc and alpha-antagnoism that is common to all quinine derivative
Why is primaquine unique?
Only drug that inhibitis exoerythrocytic schyzogony(Liver form of parasite)
What medicine can you use to help out chloroquine fight chloroquine-resistant malaria?
Amantadine: Positive charge helps chloroquine overcome chloroquine-resistant malaria vacuoles.
A-man brings chloroquine together. Reunited and it feels so good.
What are SERCA?
They start with Arte-
Artesunate and Artemether
Selective Endoplasmic Reticulum ATPase.
Lumefantrine is used in combination with what SERCA?
Artemether
Because it is so caring like a mother and a Loving(lumefantrine) father
How does atovaquone work?
Depolarizes parasitic mitochondria and inhibits their electron transport
What combination do you use with atovaquone?
Proguanil(chloroguanide)
How do chloroguanide work?
Inhiibit Dihydrofolate reductase inhibitors(proguanil)
Treat severe malaria & chloroquine resistant uncomplicated malaria with what 3 antibiotics
DCT
Doxycycline
Clindamycin
Tetracycline
what is the side effect of doxycycline?
Photosensitivty
