Adrenergic Receptor Agonist

Question 1

What are the non-selective agonist?

Answer 1

Norepinephrine and Epinephrine

Question 2

What is the only alpha-1 agonist and it’s action?

Answer 2

Phenylephrine. Theurapeutic: nasal congestion. S.E.: Postural hypotension

Question 3

What are the alpha-2 agonist and it’s action?

Answer 3

Clonidine and Methyl-dopa. Hypertension. S.E.: Sedation

Question 4

What is the only beta-1 agonist?

Answer 4

Dobutamine. Like Do is the first in do-re-mi

Use for CHF used to increase cardiac output.

Question 5

What the B2 selective agonist?

Answer 5

Think asthma and bronchodilation

Albuterol and Terbutaline

Question 6

What is the only MIXED Beta agonist?

Answer 6

Ephedrine has direct and indirect beta agonist

Question 7

What is the only non-selective Beta agonist?

Answer 7

Isoproterenol

Question 8

How to differentiate between N.E. and Epi?

Answer 8

Epinephrine can lower BP, because of B2 receptor.

Also because the B2 receptor is not innervated N.E. cannot reach the receptor.

Question 9

How to differentiate between Epi and Isoproterenol?

Answer 9

Low concentration beta response dominate, so only pick epi if you’re sure

Question 10

How to differentiate between between Epi and dobutamine?

Answer 10

Medium does epi just like dobutamine.

Epi has B2 response(vasodilation) is physiologic antagonism by alpha 1(vasoconstriction).

Therefore, epinephrine has a Beta-1 response just like dobutamine that causes tachycardia, BUT NO CHANGE IN MAP