Dermatopathology

Question 1

Hydrocortisone is used to treat?

Answer 1

Dermatitis and Psoriasis

Question 2

What is a possible side effect of hydrocortisone?

Answer 2

Atrophy/thinning of skin(collagen)

Stretch marks

Question 3

How many classes of hydrocortisone are there? Which is the strongest and which is the weakest?

Answer 3

7 classes
Class I - strongest
Class VII - weakest

Question 4

What do cyclosporine treat?

Answer 4

Inflammatory conditions(psoriarsis)

Question 5

What is side effect of cyclosporine?

Answer 5

Raise blood pressure

Damage kidneys

Question 6

What is the mechanism of methotrexate?

Answer 6

Inhibits DHFR

Question 7

What does methotrexate treat?

Answer 7

Psoriasis

Question 8

What are side effects of methotrexate?

Answer 8

Hepatotoxicity(slowly)
Pulmonary toxicity(quickly)

Question 9

How does UV light therapy work(mechanism)?

Answer 9

Immunosuppression of T cell via type I or type II reactions –> mono or bifunctional adducts in DNA

Question 10

What conditions is UV therapy good for?

Answer 10

Inflammatory conditions:
Atopic dermatitis
Lichen planus
Psoriasis

Question 11

Side effect of UV light therapy?

Answer 11

Skin cancer

Thinning/leathering of skin

Question 12

What is the drug class of isoTREtinoin?

Answer 12

Retinoid

Question 13

What is the mechanism for isoTREtinoin?

Answer 13

Stimulate epithelial cell turnover

Also anti-inflammatory

Question 14

What is disease does isoTREtinoin treat?

Answer 14

Acne

Question 15

What is the drug class of aciTREtin?

Answer 15

Retinoid

Question 16

What is the mechansim of aciTREtin?

Answer 16

Stimulate epithelial cell turnover

Question 17

What disease does aciTREtin treat?

Answer 17

Psoriasis

Question 18

What is the difference between aciTREtin and isotretinion side effect?

Answer 18

Acitretin - Teratogenic effects(stays in fat stores for 3 years)
Isotretinoin- Teratogenic effect(washes out in 3 weeks)