Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology 2 > DMARDs > Flashcards

DMARDs Flashcards

1
Q

What are DMARDs and why are they used with NSAIDs

A

Disease modifying antirheumatic Drugs

They are used with NSAIDs because it they 2 weeks to work.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What drug is both a DMARD and antimalarial?

A

Quinolones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Mechanism of Quinolones?

A

Reduce T-cell activation and chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When are Quinolones used?

A

For patients who no longer respond to NSAIDs or can’t tolerate other DMARDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is a side effect of Quinolone?

A

Retinal damage(chloroquine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Benefit of glucocorticoid in comparison to other DMARDs? What other drug is like this?

A

Fast acting can become effective before other drugs.

Acute monoarticular gout

Sulfasalazine(inhibitor of TNF and IL-1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Mechanism of glucocorticoids?

A

Inhibits phospholipase A2(inhibits formation of TXA2)

Inhibits COX2 induction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Possible side effect of glucocortioids

A

Cushingoid symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the gold standard for rheumatoid arthritis treatment?

A

Methotrexate

Inhibits AICAR and causes immunosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the mechanism of leflunomide?

A

DHODH inhibits T-lymphocyte response to stimuli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Why is Etanercept unique?

A

Blocks binding to TNF to TNF receptor. The -cept stands for receptor .

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the antibodies that bind to TNF?

A 
CAGIE
Certolizumab
Adalimumab
Golimumab
Infliximab
Etanercept
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which antibody binds to IL-1?

A

Anakinra = Anak1nra

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which antibody binds to IL-6?

A

Toclizumab = To6zumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which antibody binds to B-cells?

A

Rituximab -> binds anti-CD20 mAb, reduces circulating B cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which Drugs(biologic response modifier) are used for RA refractory to TNF-alpha inhibitors?

A

Rituximab

Abatacept(also refractory to MTX)

17
Q

What is the action of abatacept?

A

Inhibits T cell activation and induces T cell apoptosis

18
Q

Which drugs are used to treat tophaceous gout?

A 
FAPP
Febuxostat
Allopurinol
Probenecid
Pegloticase
19
Q

How does probenecid work?

A

Inhibit urate reabsorption in renal tubule

20
Q

How does allopurinol work?

A
  • Reduces uric acid synthesis by inhibiting xanthine oxidase(competitive inhibition) –> alloxanthine
  • Alloxanthine is a non-competitive inhibitor of xanthine oxidase
21
Q

How does febuxostat work?

A

Non-purine, non-competitive antagonist of xanthine oxidase.

22
Q

How does probenecid affect other drugs?

A

Secretion of some weak acids(e.g. penicillin) is reduced

23
Q

When do you colchicine?

A

Acute gouty arthritis

24
Q

How does colchicine?

A

Prevents tubulin polymerization & leads to inhibition of leukocyte migration(looks like chediak-higashi)

25
Q

What is one of the side effect of colchicine

A

Abdominal pain & diarrhea

26
Q

How does Pegloticase work?

A

Converts uric acid to ALLANTOIN

Pharmacology 2 (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions