Magnesium Disorders Physiology Mnemonics Flashcards
What does the acronym ‘MAGIC’ represent in magnesium physiology?
- M - Membrane stabilization
- A - ATP utilization (300+ enzymes)
- G - Gene expression regulation
- I - Ion channel modulation
- C - Cardiac rhythm maintenance
Mnemonic for key functions of magnesium
What does ‘TRPM6’ stand for in the context of DCT absorption?
- T - Transporter
- R - Regulated by
- P - PTH and
- M - Mg²⁺ levels
- 6 - 6th chromosome (gene location)
Mnemonic for understanding magnesium transporter in DCT
What does the acronym ‘BONE’ indicate about magnesium storage?
- B - Biggest reservoir (67%)
- O - Osteocytes incorporate it
- N - Not readily available
- E - Exchangeable surface pool
Mnemonic for major storage site of magnesium
What does ‘LOOP’ refer to in thick ascending limb handling?
- L - Lumen-positive voltage drives
- O - Obligatory paracellular
- O - Osmotic gradient dependent
- P - Passive reabsorption
Mnemonic for mechanisms in thick ascending limb of the nephron
What does ‘DCT VIP’ signify in distal regulation of magnesium?
- D - Determines final excretion
- C - Critical TRPM6 channel
- T - Tightly regulated
- V - Vitamin D enhances
- I - Insulin/PTH modulate
- P - Proton pump inhibitors affect
Mnemonic for understanding magnesium regulation in the distal convoluted tubule
What symptoms does the mnemonic ‘MAGNESIUM DEFICIT’ cover?
- M - Muscle cramps
- A - Arrhythmias
- G - GI upset
- N - Nystagmus
- E - EKG changes (prolonged QT)
- S - Seizures
- I - Irritability
- U - Unsteady gait
- M - Mental status changes
Mnemonic for symptoms of magnesium deficiency
What does ‘FXYD2’ represent regarding magnesium’s basolateral exit?
- F - Facilitates Mg²⁺
- X - Exit from cell
- Y - Yonder membrane
- D - Dependent on Na⁺/K⁺-ATPase
- 2 - 2nd messenger needed
Mnemonic for understanding magnesium exit mechanisms from cells
What does the acronym ‘CLAUdins’ indicate in TAL transport?
- C - Channel-forming
- L - Lost in mutations
- A - Allow paracellular
- U - Uptake of Mg²⁺
- D - Deficiency causes renal wasting
Mnemonic for transport mechanisms in the thick ascending limb
What does the ‘3-2-1 Rule’ help to remember regarding magnesium distribution?
- 3 - Compartments (bone, muscle, ECF)
- 2 - % in ECF
- 1 - % is free/active
Mnemonic for distribution of magnesium in the body
What does the ‘60-30-10’ rule refer to in plasma binding of magnesium?
- 60% - Free
- 30% - Albumin-bound
- 10% - Complexed
Mnemonic for understanding magnesium binding in plasma
What does the ‘5-70-25’ rule indicate regarding renal handling of magnesium?
- 5% - Excreted normally
- 70% - Reabsorbed in TAL
- 25% - In other segments
Mnemonic for renal handling of magnesium
