macrolides

Question 1

Question: What is the purpose of macrolides in the context of penicillin allergies?
Answer: Macrolides serve as an alternative in penicillin-allergic patients due to their antibacterial spectrum, similar but not identical to penicillin.

Question: What are some common indications for using macrolides?
Answer: Macrolides are indicated for various infections, including campylobacter enteritis, respiratory infections (such as pneumonia, whooping cough, Legionella, chlamydia, and mycoplasma infections), and skin infections.

Question: Which macrolide can be used in the treatment of early syphilis and genital chlamydial infection?
Answer: Erythromycin can be used for early syphilis and uncomplicated genital chlamydial infection treatment. However, it has poor activity against Haemophilus influenzae.

Question: What are some characteristics of azithromycin?
Answer: Azithromycin has slightly less activity against Gram-positive bacteria compared to erythromycin but is more effective against some Gram-negative organisms, including H. influenzae. It has low plasma concentrations but higher tissue concentrations, a long tissue half-life, and is typically dosed once daily.

Question: How does clarithromycin compare to erythromycin?
Answer: Clarithromycin is a macrolide derivative with slightly greater activity than erythromycin. It offers higher tissue concentrations and is also used in regimens for Helicobacter pylori eradication.

Question: In what context is spiramycin used?
Answer: Spiramycin is a macrolide used for the treatment of toxoplasmosis.

Answer 1

Question: What is the purpose of macrolides in the context of penicillin allergies?
Answer: Macrolides serve as an alternative in penicillin-allergic patients due to their antibacterial spectrum, similar but not identical to penicillin.

Question: What are some common indications for using macrolides?
Answer: Macrolides are indicated for various infections, including campylobacter enteritis, respiratory infections (such as pneumonia, whooping cough, Legionella, chlamydia, and mycoplasma infections), and skin infections.

Question: Which macrolide can be used in the treatment of early syphilis and genital chlamydial infection?
Answer: Erythromycin can be used for early syphilis and uncomplicated genital chlamydial infection treatment. However, it has poor activity against Haemophilus influenzae.

Question: What are some characteristics of azithromycin?
Answer: Azithromycin has slightly less activity against Gram-positive bacteria compared to erythromycin but is more effective against some Gram-negative organisms, including H. influenzae. It has low plasma concentrations but higher tissue concentrations, a long tissue half-life, and is typically dosed once daily.

Question: How does clarithromycin compare to erythromycin?
Answer: Clarithromycin is a macrolide derivative with slightly greater activity than erythromycin. It offers higher tissue concentrations and is also used in regimens for Helicobacter pylori eradication.

Question: In what context is spiramycin used?
Answer: Spiramycin is a macrolide used for the treatment of toxoplasmosis.

Question 2

cautionary and advisory labels

Answer 2

Do not take indigestion remedies 2 hours before or after you take this medicine

Take medicine with or after food

Question 3

SIDE EFFECTS

Answer 3

QT prolongation
arrythmias

Question 4

At High doses

Answer 4

cause OTOtoxicity, hepatotoxicity
hearing should be checked in pt on long term macrolides.

Question 5

INTERACTIONS

Answer 5

potent cyp inhibitor so increase warfarin conc and statins increases the risk of mypoathy.

since QT prolongation is a concern so can interact with meds that causeQT prolongation like SSRIS, Arrythmic drugs, diltiazem etc.