Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology 3 > Lytic viruses > Flashcards

Lytic viruses Flashcards

1
Q

INitially during infection at the early stage, where is the viral concentration

A

LOW~~ the virus is naked and will begin to rapidly replicate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q 
Picornavirus:
size
morphology
lipid envelope:
tegumnet:
A 
22-30nm
icosahedral
\+ssRNA
NO envelope
NO tegument
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

pH of
enterovirus
rhinovirus
(both are picornavirus)

A 
enterovirus = stable pH 3-9
Rhinorviurs = unstable below 6
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Nucleac acid polartity of picornavirus

A

+ssRNA, Icosahedral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

diseases associated with picornaviruses

Enterovirus

A

Paralysis, cold, neningitis, diarrhea, hand/foot mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

diseases associated with picornaviruses

rhinovirus

A

common cold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

diseases associated with picornaviruses

hepatovirus

A

hepatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

diseases associated with picornaviruses

haprechovirus

A

GI, myocarditis, encehpalitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

diseases associated with picornaviruses

Kobovuris

A

Gastroenteritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Capsid of enterovirus: resistant to mild sewage tx, salt water, detergents and temp changes… thus viruse can transmit via

A

fecal-oral routes, fomties and on hands:

see that it goes through sewage and landfills→ into water supply→ and to us

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Even though picornavirus have many simular morphologies, they can have different

A

receptors on cell surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Virus recovered from throat/stool

Asymptomatic

A

Inapparent (subclinical) 90-95% polio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Minor undifferntiated febrile illness

Influenza like or URI

A

Mild illness (4-8%) from polio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Minor illness progresses to CNS invasion

Stiff back and neck, lasts 2-10 days with rapid and complete recovery

A

Aseptic Meningitis (nonparalytic polio) 1-2%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Graymarrow inflammation, initially nonspecific febrile diseae w/ varialbe spectrum of paralysis; can see isolated msl groups or extensive paralysis

A

Paralytic poliomyletis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

patterns of polio paralysis

A

Asymmetric flaccid paralysis, lower extremeties more affected, large msl grous often affected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Bulbar paralysis: i

A

involvement of CN’s—respiratory compromise and 5% death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

recovery from parayltic poliomyletis

A

Slow recovery from this (2 years 100%) or residual paralysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

IG: the virus will go into the gut and intestine, stay there and

A

is shed in feces… only see complications

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Polio can go → lymph nodes-→ enters blood stream and gets into liver and spleen causing______ (febrile illness) and can cross into CSF causesing _______or attack the gray matter causing ________

A

viremia
(aseptic menigitis)
(paralytic poliomyletis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Virus Isolation gotten from

A

Stool species, throat washings
CSF
Specifc, sensitive, time consuming

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

how do we commonly identify polio no

A

PCR

can so serology too,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

General: ancient disease. Polio is exclusievely_____, fecal-oral transmission and enhanced by persons w/ sub-clinical infections seen during

A

human

Summer Epidemics d/t pool transmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

cause of early Endemic

A

EARLY in history children encounter the virus at early age and were protected by mothers antibodies… high rate of subclincal infections with a low incidence of paralytic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Epidemic in early 1900 of polio

A

get indoor plumbing so pts are older when they first encounter virus and no longer have maternal antiBs. Higher incidence of paralytic diseae in older children/adults

26
Q

Post-vaccine:

A

small number of cases and most all cases are vaccine related.

27
Q

Picovirus interacts with receptors on cell surface→ this____ the capsid

A

weakens

28
Q

Genome is_______ through the virion across the cell mmb OR virion is ______and genome is released

A

injected

endocytosed

29
Q

Genome initially released from polio virus is used as mRNA for protein synthesis to make ______polyprotein

A

ONE

30
Q

ONE polyprotein is cleaved to many little proteins including an

A

RNA-dependent RNA polymerase

31
Q

RNA polymerase makes a ____strand template from the genome and replicates the genome with a protein _____covalently attached to the 5’ end

A

(-)

VPg

32
Q

Structual prteons associate into the capsid, the genome is insereted and virions are releaed during

A

cell lysis

33
Q

How does the piocornavirus enter

A

Entry: picovirus has a canyon structure on its surface… this is where the receptor binds from host cell so it can adhere
a. the canyon is an excellent target for antivirals

34
Q

The virus must go: VPg———————-3 ‘ (+)RNA → 3’—————-VPg (–)RNA because

A

so it can make +sense copies

35
Q

During proteolytic processing; the virus will ______translation of host cell and plays a role in cell death

A

inhibit

36
Q

Why doesn’t the poliovirus genome go to the nucleus once it’s injected

A

The Genome can stay in the cytoplasm because it’s already a +RNA and doesn’t need to use host nucleus

37
Q

Picornavirus prevention and control:

A

block virus attachment
virust entry and genome release
protease processing
RNA-dependent RNA polymerase inhibitors

38
Q

Polio will Attach to _____Receptor in lung and spread to viremia if go into CNS get encephalitis and paralysis and if go through CSF get meningitis

A

CD55

39
Q

Issues with the – sense RNA viruses

A

cannot translate their own and need to get to a +RNA thus need to bring along their own enZs to get it done; start to see they get bigger and bulkier

40
Q

–can be non-segmtented or segmented genomes thus each segment transcribed sepearately

A

Negative strand RNA viruses

41
Q

segmented genomes with each segment transcribed separate to produce monocistronic mRNAs

A

dsRNA (reovirus):

42
Q

dsRNA (reovirus): segmented genomes with each segment transcribed separate to produce

A

monocistronic mRNAs

43
Q

From adenoid tissues and and see latent virus there

A

Adenovirus

44
Q

Adenovirus:
genome
enveloped?

A

dsDNA

NOT enveloped

45
Q

adenovirus is spread:

A

fecal ora l and some respiratory

46
Q

Disease associated with adenovirus

A

uapparent respiratory

47
Q

Adenovirus apperance

A

isosahedral capsid with penton spikes

48
Q

isosahedral capsid with penton spikes

A

Adenovirus

49
Q

VERY complicated compared to piconavirus –needs own machinary and unique binding proteins

A

Adenovirus

50
Q

Progression of disease with Adenovirus

A

Enter URT or GI then go to lymph nodes get viremia and then go systemic (disease of URT, conjuctivitis, GI, hemorrhagic cystitis (inflammation bladder) URT- go systemic and cause productive, persistent (lymph nodes), or latent infection

51
Q

From URT, adenovirus

A

URT- go systemic and cause productive, persistent (lymph nodes), or latent infection

52
Q

Viral lifecycle of adenovirus

A

Attach to DAF, migrate virus to clathirin pit, and then endocytosed or fused, shed into intestinal surface via penton spike fibers on capsule causing disruption adhesion juctions, enter nucleus using hexons, transcibe early and late genes which are spliced extensively

53
Q

adenovirus will have interction with _____ and myosin as it surfs along

A

DAF

54
Q

Adenovirus will engage with with receptor inthe carthrin coated pits

A

CAR receptor

55
Q

What is the viral fusion protein for Adenovirus

A

PIV-3

56
Q

The Adenovirus has introns and splicing events because

A

its a complex genome and thus you generate more proteins

57
Q

Order of Production and release of adenovirus from epithelial cells

A
  1. Virus released from BASAL surface
  2. Excessive virus penton spike fibers released form cells disrupt cell adhehion jnx
  3. Virus passes up to apical layer an shed into intestinal lumen
  4. virus attaches to apical surface
58
Q

splicing was first discovered in

A

adenoviruses

59
Q

multiple spiced mRNAs and alternative splicing are used to make a variety of polypeptides from:

A

each promoter

60
Q

Adenovirus intracellular production

A
  1. Mature virion will attach to cell and loses its spikes→ goes in a penton
  2. Penton releases→ Hexon with helical info
  3. Hexons deliver viral dna into the nucleus and use host nulcear stuff to take dna→ rna
61
Q

Transcriptional program is a stepwise process with precise

A

timing of translation

62
Q

Adenovirus vaccine is made and administered to

A

armed forces

Immunology 3 (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions