Hep Virus information

Question 1

Spread via injected drugs, sex, transfusion

Answer 1

Hep C

Question 2

Does Hep C have an envelope

Answer 2

yes

Yes (LDL and HDL)

Question 3

Hep C genome

Answer 3

ssRNA (+)

Question 4

Hep C virus family

Answer 4

Flavivirus

Question 5

Entry, Uncoating, IRES mediated translation, 10 proteins generated via proteolytic processing, RNA replication in membranous web, then assembled and shed

Answer 5

Hep C

Question 6

Hep C will enter–> uncoat–> and has ______ mediated translation

Answer 6

IRES

Question 7

Hep C: the IRES medated translation gives us ____ proteins generated via proteolytic processing

Answer 7

10

Question 8

Where does RNA replication happen

Answer 8

in the membranous web… assembled, then shed

Question 9

Screening for Hep C and tx

Answer 9

Blood Supply Screened, IFN and Ribavirin also protease inhibitor (for genotype 1), target translation enhancing miRNA-122

Question 10

target what aspect of Hep C

Answer 10

miRNA-122

Question 11

Identification for Hep C

Answer 11

NO culture system

Question 12

Symptoms of Hep C in adults:

Answer 12

90 %- Resolution (good immune response), 9%- HbsAg-Resolution, Carrier, Chronic persistent hepatitis (mild immune response) and chronic active hepatitis which leads to hepatic cell carcinoma, cirrhosis, and golmerulonephritis especially if Hep D viriod present

Question 13

Hep C: 9%- _______, Carrier, Chronic persistent hepatitis (mild immune response) and chronic active hepatitis which leads to hepatic cell carcinoma, cirrhosis, and golmerulonephritis especially if Hep D viriod present

Answer 13

HbsAg-Resolution

Question 14

Cancer due to integration into host chromosome, X protein decreasing p53 activity

Answer 14

Hep C