Lymphoreticular Patho Pots

Question 1

G: Tuberculous Lymphadenitis (3)

Answer 1

1. lymph nodes enlarged and matted into confluent mass
2. cut surface is pale, nodular
3. friable, caseous necrosis

Question 2

H: tuberculous lymphadenitis (1)

Answer 2

1. granulomatous inflammation - epithelioid histiocytes, ring of T-lymphocytes, langhans giant cells, central necrosis

Question 3

G: Classical Hodgkin’s Lympohoma (1)

Answer 3

1. cut surface shows matted, pale homogenous surface

Question 4

H: Classical Hodgkins Lymphoma (3)

Answer 4

Reed Sternberg cells
1. Prominent nucleoli
2. binucleated, mirrored, Owls eye appearances
3. eosinophillic background, macrophages and lymphocytes

Question 5

G: Large Cell Lymphoma (3)

Answer 5

1. enlarged lymph nodes
2. cut surface matted and tan, fleshy
3. necrosis

Question 6

Markers for Classical hodgkins Lymphoma

Answer 6

B cell markers: CD20-, BCL6-, CD45-
CD15+ and CD30+

Question 7

M: follicular lymphoma

Answer 7

B-cell marker: CD20+
Follicular Center marker: CD10+, BCL6+
Specific Marker: BCL2+

t(14:18) translocation
upregulation of BCL2+ oncogene

Question 8

H: Diffuse Large B cell lymphoma (5)

Answer 8

1. loss of lymph node architecture, loss of germinal centres
2. abnormally large B cell lymphocytes
3. multiple nucleoli
4. vesicular nucleus dispersed chromatin
5. apoptopic cells
   lymphoma cells not hyperchromatic

Question 9

M: Diffuse Large B cell lymphoma

Answer 9

B-cell marker: CD20+, CD19+

no clear defining molecular signature

Question 10

H: Burkitts Lymphoma (2)

Answer 10

1. loss of follicular structure
2. Starry Sky appearance - due to rapid cell turnover and phagocytosis by macrophages

Question 11

M: Burkitts Lymphoma

Answer 11

B-cell marker: CD20+
Follicular cell marker: CD10+
Specific: Ki67 proliferation 100%

t(8:14) translocation. upregulation of C-MYC oncogene and mutation to protooncogene