Gynae Patho pots Flashcards

1
Q

Gross Adenomyosis (4)

A
  1. Uterus is enlarged
  2. myometrium is diffusely thickened and trabeculated - due to expression of endometrial glands, causing overgrowth
  3. areas of haemorrhage, punctate haemorrhage - fast growing
  4. some intramural leiomyoma
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2
Q

Histo Adenomyosis (2)

A
  1. endometrial stroma
  2. endometrial glands
    in myometrium
  3. overgrowth of muscle and connective tissue
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3
Q

Gross Hydrosalpinx (2)

A
  1. fallopian tube cystically dilation
  2. normal ovaries
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4
Q

Histo Hydrosalpinx (3)

A
  1. Dilated lumen
  2. walls thickened with oedema and congestion
  3. engorged blood vessels
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5
Q

Gross Tubal Ectopic Pregnancy (2)

A
  1. dilated tubal lumen
  2. mural and luminal haemorrhage with blood clots
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6
Q

Histo Tubal Ectopic Pregnancy (5)

A
  1. Ruptured uterine tube
  2. expanding tubal wall
  3. compressed tubal lumen
  4. cytotrophoblast
  5. syncytiotrophoblast
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7
Q

Gross Tubo-Ovarian Abscess (4)

A
  1. Fallopian tube is adhered to ovary
  2. Ovary is replaced by thick abscessed wall and abscess cavity
  3. abscess wall has necrotic purulent slough, edema, congestion and haemorrhage
  4. tubes are tortuous and kinked with thickened, inflamed walls
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8
Q

Gross endometriotic Cyst (3)

A
  1. both or one ovaries large and cystic
  2. cysts have brownish areas of old haemorrhage (chocolate cyst) - due to haemosiderin deposits
  3. no solid or papillary areas
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9
Q

Histo Endometriotic cyst (3)

A
  1. cyst wall with endometrial stroma
  2. rich vascular network
  3. areas of haemorrhage lining the walls of the cyst, deposits of haemosiderin - chocolate cyst
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10
Q

Gross Leiomyoma (5)

A
  1. Uterus is assymetrically enlarged
  2. intramural mass (leiomyoma) well circumscribed and encapsulated
  3. cut surface whorled and tan coloured
  4. no necrosis or haemorrhage
  5. endometrial cavity distorted and compressed
  6. possibility of smaller leiomyoma present
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11
Q

Histo Leiomyoma (3)

A
  1. fibrous capsule, sharp demarcation from normal myometrium
  2. fascicles of smooth muscle cells - parallel growth
  3. smooth muscles cells are spindle shaped, elongated and uniform
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12
Q

Gross Endometrial Carcinoma (4)

A
  1. Large mass originating from endometrium, growth into endometrial cavity
  2. infiltrative borders, invading into myometrium
  3. mass is irregular shaped, fungating
  4. mass is tan fleshy
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13
Q

Histo endometrial Carcinoma (2)

A
  1. irregular border with malignant glands invading myometrium
  2. malignant glands are irregular, crowded and fused
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14
Q

Gross Cervical Carcinoma (6)

A
  1. nodular mass
  2. non-encapsulated, ill defined invasive borders
  3. pale tan cut surface
  4. haemorrhage and ulceration of mass
  5. endometrium shows thinning, atrophy
  6. endometrium and vaginal fornix not involved
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15
Q

Histo Cervical Carcinoma (4)

A
  1. ulcerative growth
  2. invasive borders
  3. squamous cell carcinoma shows islands of malignant squamous cells - large, keratin pearls, high N/C, atypical mitosis
  4. intercellular bridges
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16
Q

Gross Choriocarcinoma (3)

A
  1. irregular and infiltrative mass
  2. invading endometrium and underlying myometrium
  3. large areas of necrosis and haemorrhage
17
Q

Histo Choriocarcinoma (4)

A
  1. cytotrophoblast - highly pleomorphic (large)
  2. syncytiotrophoblast - multinucleated
  3. tumour invading myometrium
  4. areas of haemorrhage
18
Q

Gross Hydatidiform Mole (4)

A
  1. distended endometrial cavity
  2. proliferation of grape-like fluid vesicles varying in size - large expanded chorionic villi
  3. no invasion of uterine wall
  4. no foetus
19
Q

Histo Hydatidiform Mole (4)

A
  1. swollen chorionic villi (edema)
  2. trophoblast proliferation on villi surface
  3. central cistern within villi
  4. admixed endometrial tissue
20
Q

Serous Cystadenoma (4)

A
  1. unilocular ovarian cyst
  2. small clusters of white papillary excrescences
  3. cyst filled with clear serous fluid
  4. no solid fleshy mass - seen in serous cystadenocarcinoma
21
Q

Histo Cystadenoma (4)

A
  1. papillary projections with broad fibrous cores
  2. cystadenoma cells lining surface of papillary projections
  3. cells have ciliated columnar epi
  4. dense collagenous stroma
22
Q

Symptoms to look out for in gynae path

A
  1. heavy bleeding - anaemia
  2. cyclical symptoms
  3. vaginal discharge
  4. fever
  5. patients age and history- pre/post menopausal
  6. Pain - dysmenorrhoea
23
Q

Heavy menstruation/ Menorrhagia DDx

A
  1. Adenomyosis - increased expression of glands
  2. Leiomyoma - distortion of endometrial cavity
  3. PCOS
  4. Endometrial Carcinoma
  5. Endometrial hyperplasia
24
Q

What can cause Cyclical bleeding

A

endometriosis

25
Q

What can cause post coital bleeding seen in older women?

A
  1. Cervical Intraepithelial neoplasia
  2. Cervical carcinoma
26
Q

What causes post menopausal bleeding?

A

endometrial carcinoma
endometrial hyperplasia

27
Q

What to suspect if a patient presents with fever?

A
  • often associated with pain
    INFECTION!! - Pelvic inflammatory disease, salpingitis, pyosalpinx, tubo-ovarian abscess
28
Q

Patient presents as asymptomatic, but has abnormal PAP smear and history of multiple sex partners. What do you suspect?

A

Cervical Intraepithelial Neoplasia
need to do histo to differenciate between that and invasive squamous cell carcinoma of the cervix (invasion of basement membrane)