Breast Patho pots Flashcards
1
Q
gross features of fibrocystic change (3)
A
- mass is irregular and firm
- dense fibrosis
- cystic changes
2
Q
Histo of Fibrocystic Change (5)
A
- cystic dilation of ducts
- apocrine metaplasia - grainy cytoplasm
- epithelial hyperplasia - typically simple cuboidal epi turns stratified cuboidal
- stromal sclerosis - stromal fibrosis
- fibroadenomatoid change
3
Q
gross features of fibroadenoma (5)
A
- well-circumscribed with lobulated surface
- encapsulated
- firm
- pale tan homogenous surface
- no necrosis or haemorrhage
4
Q
histo of fibroadenoma (4)
A
- fibrous stroma
- epithelial glandular structures
- collagenous stroma with bland spindle cells
- ducts are compressed and slit like
5
Q
gross features of phyllodes (5)
A
- circumscribed
- not encapsulated
- lobulated with cleft like spaces
- pale and fleshy cut surface
- focal necrosis
6
Q
histo of phyllodes (3)
A
- leaf-like architecture, papillary fronds
- periductal condensation of cellular stroma - mesenchymal cells
- malignancy shows nuclear atypia and typical malignant features
7
Q
Gross Ductal Carcinoma (5)
A
- irregular with invasive borders
- firm mass
- pale tan fleshy cut surface
- areas of necrosis or haemorrhage
- nipple retraction and skin ulceration
8
Q
Histo Ductal Carcinoma
A
- check for invasion of basement membrane
- multifocal distribution with irregular islands of malignant cells
- desmoplastic stroma
- cribiform growth pattern
- large cell malignant features
9
Q
Ductal Carcinoma Markers
A
ER and PR positive
Her2 Negative
10
Q
Gross Pagets disease
A
nipple shows erosion, redness, scaling and crusting
11
Q
Histo Pagets Disease (5)
A
- epithelium shows abnormal glandular cells
- single cells or small clusters
- large with prominnt nucleoli
- abundant light staining cytoplasm
- spread along lactiferous ducts along squamous epithelium of nipple
