Lymphomas & Plasma Cell Dyscrasias Flashcards
List the 4 Lymphomas & Plasma Cell Dyscrasias:
Hodgkins, Non-Hodgkins, Multiple Myeloma, Burkitt’s
What previous illnesses increase the risk of developing Hodgkins Lymphoma?
EBV, Mono, autoimmune disorders
What symptoms do patients with Hodgkins Lymphoma present with?
Non-tender, swollen lymph nodes, usually in the neck, mediastinal mass, pain swallowing alcohol, pruritis
Hodgkins Lymphoma affects people of what ages?
young adult
What is the hallmark lab finding of Hodgkins Lymphoma (that separates it from Non-Hodgkins Lymphoma)?
Biopsy will show large, bi-lobed B-cells, w/germinal center called Reed Sternberg Lymphocytes (“owl’s eye on inflamed background”)
Treatment for Hodgkins Lymphoma
Chemotherapy
What symptoms will patients with Non-Hodgkins Lymphoma present with?
Can be same as Hodgkins (lymph adenopathy) also hepatosplenomegaly, fever, weight loss, night sweats.
Differences between Hodgkins & Non-Hodgkins?
Hodgkins - affects younger demographic, presence of Reed Sternberg cells; hodgkins is more treatable…
Malignancy of Plasma cells; disease where stem cells terminally differentiate as plasma cells
Multiple Myeloma
Signs and symptoms of Multiple Myeloma:
bone pain, fatigue/weakness, recurrent infections
Typical presentation of multiple myeloma:
CRAB: Calcium elevated, renal insufficiency, Anemia, Bone lesions
Treatment for Multiple Myeloma:
Not curable but its course can be slowed down by stem cell transplant, chemotherapy, cancer drugs
Which is the fastest growing of all lymphomas?
Burkitt’s Lymphoma?
Where is Burkitt’s Lymphoma most commonly found?
Africa
Which diseases are believed to cause Burkitt’s Lymphoma?
EBV, malaria
