Disorders of Hemostasis Flashcards
Name the 5 disorders of hemostasis:
Immune Thrombocytopenic Purpura (ITP), Thrombotic Thrombycytopenic Purpura (TTP), Hemolytic-Uremic Syndrome, Henoch-Schonlein Purpura, Heparin-Induced Thrombocytopenia (HIT)
What is the pathophysiology of Idiopathic Thrombocytopenic Purpura (ITP)?
Autoimmune; body makes antibodies that go and attack platelets, leading to decreased platelet count.
Who is most likely to get ITP?
Children more often than adults / women more often than men
What often precedes ITP?
A viral infection.
Labs for ITP?
Low platelets & everything else is largely normal
Signs and symptoms of ITP?
Petechiae, purpura, spontaneous bleeding, blood cannot clot
What differentiates ITP from Thrombotic Thrombocytopenic Purpura?
TTP is considered a “Thrombotic Microangiopathy.” Clots form in very small vessels, leading to decreased platelet count.
What might you find in the blood in someone with TTP?
Von Wilibrand Factor
What are key symptoms of TTP?
Fever and neurologic problems
What two types of hemostasis disorders involve both thrombocytopenia and microangiopathy?
TTP and Hemolytic Uremic Syndrome
What does Hemolytic Uremic Syndrome often follow?
Diarrhea caused by shiga-like toxin that causes microvascular injury
What is the most common cause of kidney failure in kids?
Hemolytic Uremic Syndrome
What distinguishes Henoch Schonlein Purpura from the other two types of purpura?
It is not a thrombocytopenic condition - platelets aren’t necessarily low.
What causes HS Purpura?
Vessel inflammation often following pathogenic virus
What is Heparin Induced Thrombocytopenia?
It is what happens when Heparin does the reverse of what it’s supposed to do… instead of causing the blood to thin, Heparin instead causes the blood to clot & thus platelet level tanks.
