Hereditary Disorders of Coagulation Flashcards
Name the 3 hereditary disorders of coagulation:
Hemophilia A, von Willebrand Factor, Hemophilia B
Name the 3 hereditary disorders of coagulation:
Hemophilia A, von Willebrand Factor, Hemophilia B
Hemophilia A involves what clotting factor?
Factor VIII; people with Hemophilia A make factors that inhibit Factor VIII
Hemophilia B involves what clotting factor?
Factor IX; people with heme B make factors that inhibit Factor IX
Genetics of Hemophilia A and B
X-linked recessive; most women are carriers, most men are affected
What is the most common bleeding disorder?
von Wilibrands
What does von wilibrand factor do?
It’s a glycoprotein that sticks platelets together and to the injured endothelial surface; it also has a binding site for factor VIII, prolonging its presence in circulation
How many types of Von wilibrands disease are there?
Three - type I, II, and III
Describe each of the types of von Wilibrands disease.
Type I - bleeding limited primarily to mucosal membranes, not serious; most common. Type II - Moderate to severe bleeding, noticed in adolescents; Type III - major bleeding, discovered at infancy.
Hemophilia A involves what clotting factor?
Factor VIII; people with Hemophilia A make factors that inhibit Factor VIII
Hemophilia B involves what clotting factor?
Factor IX; people with heme B make factors that inhibit Factor IX
Genetics of Hemophilia A and B
X-linked recessive; most women are carriers, most men are affected
What is the most common bleeding disorder?
von Wilibrands
What does von wilibrand factor do?
It’s a glycoprotein that sticks platelets together and to the injured endothelial surface; it also has a binding site for factor VIII, prolonging its presence in circulation
How many types of Von wilibrands disease are there?
Three - type I, II, and III
