Acquired Disorders of Coagulation

Question 1

Name the 4 acquired disorders of coagulation:

Answer 1

Vitamin K deficiency, disseminated intravascular coagulation, coagulopathy of liver disease, acquired platelet disorders

Question 2

What causes Vitamin K deficiency?

Answer 2

Dietary intake, poor absorption, chemotherapy

Question 3

What role does Vitamin K play in clotting?

Answer 3

Vitamin K plays a role in forming the protein that forms Factors II, VII, IX, X

Question 4

When is DIC most likely to occur?

Answer 4

During pregnancy or when someone has cancer - it is a secondary condition

Question 5

What is the pathophyisiology of DIC?

Answer 5

The entire coagulation cascade gets activated. Micro clots form all over the place; these clots use up all of the platelets, fibrin, and fibrinogen, ironically, causing bleeding… so - bleeding and clotting are occurring at the same time.

Question 6

Management of DIC?

Answer 6

Heparin will make worse - give platelets and/or plasma

Question 7

What are the signs and symptoms of liver disease?

Answer 7

Like in DIC, clots form in the liver, using up clotting material from elsewhere, causing bleeding.

Question 8

Platelet dysfunction is often caused by:

Answer 8

Drugs

Question 9

Drugs that cause platelet dysfunction?

Answer 9

NSAIDs, IBU, Ometa 3 fatty acid, alcohol, abx