Lymphomas Flashcards
Anaplastic Large Cell Lymphoma
Children and Young Adults
Aggressive
Large “Epitheloid” lymphocytes
t(2,5)
Alk-1 protein expression
Peripheral T cell Lymphoma
Middle aged and elderly
Aggressive
Large T cells
Adult T cell leukaemia/lymphoma
Caribbean and Japanese
HTLV1 Infection
Aggressive
Enteropathy-associated T cell lymphoma (EATL)
Long-standing Coeliac’s
Cutaneous T cell lymphoma
Mycosis fungoides
Burkitt’s Lymphoma
Very Agressive
Fast-growing
T(8,14) translocation
C-myc over expression
“Starry-sky” appearance
All treated with Rituximab (anti-CD20)
Endemic: Equatorial Africa, EBV-associated, “jaw involvement” and abdominal masses
Sporadic: EBV-associated, jaw less likely
Immunodeficiency: Non-EBV associated, post-transplant, HIV
Diffuse Large B Cell Lymphoma
“Sheets of large lymphoid cells”
Middle ages and elderly
Aggressive
Ritcher’s transformation
From chronic lymphocytic leukemia (CLL) and hairy cell leukemia —> DLBL
Mantle Cell Lymphoma
“Angular nuclei”
Middle aged
M>F
Aggressive
Disseminated at presentation
T(11.14)
Cyclin D1 deregulation
median survival 3-5 yrs
Follicular Lymphoma
“Follicular pattern”
“Nodular appearance”
Indolent
Incurable (mostly)
Median survival 12-15 years
T(14,18)
MALToma
H.pylori –> MALToma
T(11;18)
Sjogren’s –> Parotid lymphoma
Rituximab-CHOP
R- Retuximab
CHOP Cyclophosphamide 750 mg/m2 i.v. D1 Adriamycin 50 mg/m2 i.v. D1 Vincristine 1.4 mg/m2 i.v. D1 Prednisolone 40 mg/m2 p.o. D1‑D5
Multiple Myeloma
Plasma cell neoplasm
“Bence-Jones” proteins in urine
Raised ESR
Rouleaux on blood film
Dense narrow band on electrophoresis
> 10% plasma cells in bone marrow
Calcium (high) (moans, groans, thrones, stones)
Renal impairment (+amyloidosis and nephrotic syndrome)
Anaemia (+pancytopenia)
Bone pain (pepper pot skull, wedge compression, fractures, osteolytic lesions)
Hyperviscosity syndrome
Treatment of multiple myeloma
Melphalan Bortezomib (protease inhibitor) Lebalidomide Thalidoamide Steroids
Auto- SCT
Supportive: bisphosphonates
Children and Young Adults
Aggressive
Large “Epitheloid” lymphocytes
t(2,5)
Alk-1 protein expression
Anaplastic Large Cell Lymphoma
Middle aged and elderly
Aggressive
Large T cells
Peripheral T cell Lymphoma